Inosine monophosphate synthase

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ATIC
Protein ATIC PDB 1p4r.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ATIC, AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
External IDs OMIM: 601731 MGI: 1351352 HomoloGene: 2983 GeneCards: ATIC
RNA expression pattern
PBB GE ATIC 208758 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004044

NM_026195

RefSeq (protein)

NP_004035

NP_080471.2
NP_080471

Location (UCSC) Chr 2: 215.31 – 215.35 Mb Chr 1: 71.56 – 71.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.[3][4][5]

ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.

It has two functions:

  • EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
  • EC 3.5.4.10 - IMP cyclohydrolase

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Rayl EA, Moroson BA, Beardsley GP (Mar 1996). "The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping". J Biol Chem. 271 (4): 2225–33. doi:10.1074/jbc.271.4.2225. PMID 8567683. 
  4. ^ Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). "Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase". J Biochem. 122 (2): 309–13. doi:10.1093/oxfordjournals.jbchem.a021754. PMID 9378707. 
  5. ^ "Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase". 

Further reading[edit]

External links[edit]