Inositol-phosphate phosphatase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
inositol-1(or 4)-monophosphatase
2czi.jpg
Inositol monophosphatase 2, dimer, Human
Identifiers
EC number3.1.3.25
CAS number37184-63-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an inositol-phosphate phosphatase (EC 3.1.3.25) is an enzyme that catalyzes the chemical reaction

myo-inositol phosphate + H2O myo-inositol + phosphate

Thus, the two substrates of this enzyme are myo-inositol phosphate and H2O, whereas its two products are myo-inositol and phosphate.

This enzyme participates in 3 metabolic pathways: streptomycin biosynthesis, inositol phosphate metabolism, and phosphatidylinositol signaling system.

Nomenclature[edit]

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is myo-inositol-phosphate phosphohydrolase. Other names in common use include:

  • myo-inositol-1(or 4)-monophosphatase,
  • inositol 1-phosphatase,
  • L-myo-inositol-1-phosphate phosphatase,
  • myo-inositol 1-phosphatase,
  • inositol phosphatase,
  • inositol monophosphate phosphatase,
  • inositol-1(or 4)-monophosphatase,
  • myo-inositol-1(or 4)-phosphate phosphohydrolase,
  • myo-inositol monophosphatase, and
  • myo-inositol-1-phosphatase.

References[edit]

  • Eisenberg F Jr (1967). "D-myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis". J. Biol. Chem. 242 (7): 1375&ndash, 82. PMID 4290245.
  • Shute JK; Ragan, CI; Watling, KJ; Aspley, S; Jackson, RG; Reid, GG; Gani, D; Shute, JK (1988). "The purification and properties of myo-inositol monophosphatase from bovine brain". Biochem. J. 249 (3): 883&ndash, 9. PMC 1148789. PMID 2833231.
  • Hallcher LM, Sherman WR (1980). "The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain". J. Biol. Chem. 255 (22): 10896&ndash, 901. PMID 6253491.
  • Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol. Psychiatry. 2 (5): 393&ndash, 7. doi:10.1038/sj.mp.4000325. PMID 9322233.
  • Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
  • Ackermann KE, Gish BG, Honchar MP, Sherman WR (1987). "Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism". Biochem. J. 242 (2): 517&ndash, 24. PMC 1147736. PMID 3036092.