Inositol-phosphate phosphatase

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inositol-1(or 4)-monophosphatase
Inositol monophosphatase 2, dimer, Human
EC number3.1.3.25
CAS number37184-63-7
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an inositol-phosphate phosphatase (EC is an enzyme that catalyzes the chemical reaction

myo-inositol phosphate + H2O myo-inositol + phosphate

Thus, the two substrates of this enzyme are myo-inositol phosphate and H2O, whereas its two products are myo-inositol and phosphate.

This enzyme participates in 3 metabolic pathways: streptomycin biosynthesis, inositol phosphate metabolism, and phosphatidylinositol signaling system.


This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is myo-inositol-phosphate phosphohydrolase. Other names in common use include:

  • myo-inositol-1(or 4)-monophosphatase,
  • inositol 1-phosphatase,
  • L-myo-inositol-1-phosphate phosphatase,
  • myo-inositol 1-phosphatase,
  • inositol phosphatase,
  • inositol monophosphate phosphatase,
  • inositol-1(or 4)-monophosphatase,
  • myo-inositol-1(or 4)-phosphate phosphohydrolase,
  • myo-inositol monophosphatase, and
  • myo-inositol-1-phosphatase.


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  • Shute JK; Ragan, CI; Watling, KJ; Aspley, S; Jackson, RG; Reid, GG; Gani, D; Shute, JK (1988). "The purification and properties of myo-inositol monophosphatase from bovine brain". Biochem. J. 249 (3): 883–9. PMC 1148789. PMID 2833231.
  • Hallcher LM, Sherman WR (1980). "The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain". J. Biol. Chem. 255 (22): 10896–901. PMID 6253491.
  • Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol. Psychiatry. 2 (5): 393–7. doi:10.1038/ PMID 9322233.
  • Cockcroft, S. (Ed.), Biology of Phosphoinositides, Biology of Phosphoinositides, Oxford, 2000, p. 320-338.
  • Ackermann KE, Gish BG, Honchar MP, Sherman WR (1987). "Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism". Biochem. J. 242 (2): 517–24. PMC 1147736. PMID 3036092.