Inositol monophosphatase 2

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IMPA2
Protein IMPA2 PDB 2czh.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IMPA2
External IDs MGI: 2149728 HomoloGene: 22799 GeneCards: 3613
Genetically Related Diseases
Disease Name References
stroke
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014214

NM_053261

RefSeq (protein)

NP_055029.1

NP_444491.1

Location (UCSC) Chr 18: 11.98 – 12.03 Mb Chr 18: 67.29 – 67.32 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene.[4][5] IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.[6]

References[edit]

  1. ^ "chibi.ubc.ca/Gemma/phenotypes.html?phenotypeUrlId=DOID_6713&geneId=78624". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (Nov 1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol Psychiatry. 2 (5): 393–97. doi:10.1038/sj.mp.4000325. PMID 9322233. 
  5. ^ "Entrez Gene: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2". 
  6. ^ Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (January 2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342. 

Further reading[edit]