Inositol monophosphatase 2

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Protein IMPA2 PDB 2czh.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases IMPA2, inositol monophosphatase 2
External IDs MGI: 2149728 HomoloGene: 22799 GeneCards: IMPA2
Gene location (Human)
Chromosome 18 (human)
Chr. Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for IMPA2
Genomic location for IMPA2
Band 18p11.21 Start 11,981,025 bp[1]
End 12,030,883 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 18: 11.98 – 12.03 Mb Chr 18: 67.29 – 67.32 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene.[5][6] IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141401 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024525 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (Nov 1997). "A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder". Mol Psychiatry. 2 (5): 393–97. doi:10.1038/ PMID 9322233. 
  6. ^ "Entrez Gene: IMPA2 inositol(myo)-1(or 4)-monophosphatase 2". 
  7. ^ Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (January 2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–46. doi:10.1074/jbc.M604474200. PMID 17068342. 

Further reading[edit]