Inositol oxygenase is a non-heme di-ironenzyme which oxidizes myo-inositol to glucuronic acid. It will also oxidize the less abundant chiroisomer of inositol. This enzyme is part of the only known pathway for the catabolism of inositol in humans. It is expressed mostly in the kidneys. Depletion of Inositol Oxygenase and accumulation of polyols, such as inositol and xylitol, have been cited as contributing factors in complications associated with diabetes.
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