Inositol oxygenase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
myo-inositol oxygenase
Symbol MIOX
Alt. symbols ALDRL6
Entrez 55586
HUGO 14522
OMIM 606774
RefSeq NM_017584
UniProt Q9UGB7
Other data
EC number
Locus Chr. 22 q

Inositol oxygenase is a non-heme di-iron enzyme which oxidizes myo-inositol to glucuronic acid.[1] It will also oxidize the less abundant chiro isomer of inositol.[2] This enzyme is part of the only known pathway for the catabolism of inositol in humans.[3] It is expressed mostly in the kidneys.[4][5] Depletion of Inositol Oxygenase and accumulation of polyols, such as inositol and xylitol, have been cited as contributing factors in complications associated with diabetes.[6]

See also[edit]


  1. ^ Bollinger JM, Diao Y, Matthews ML, Xing G, Krebs C (Feb 2009). "myo-Inositol oxygenase: a radical new pathway for O(2) and C-H activation at a nonheme diiron cluster". Dalton Transactions (6): 905–14. doi:10.1039/b811885j. PMID 19173070. 
  2. ^ Arner RJ, Prabhu KS, Thompson JT, Hildenbrandt GR, Liken AD, Reddy CC (Dec 2001). "myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol". The Biochemical Journal 360 (Pt 2): 313–20. doi:10.1042/0264-6021:3600313. PMC 1222231. PMID 11716759. 
  3. ^ Hankes LV, Politzer WM, Touster O, Anderson L (Oct 1969). "Myo-inositol catabolism in human pentosurics: the predominant role of the glucuronate-xylulose-pentose phosphate pathway". Annals of the New York Academy of Sciences 165 (2): 564–76. doi:10.1111/j.1749-6632.1970.tb56424.x. PMID 5259614. 
  4. ^ Reddy CC, Swan JS, Hamilton GA (Aug 1981). "myo-Inositol oxygenase from hog kidney. I. Purification and characterization of the oxygenase and of an enzyme complex containing the oxygenase and D-glucuronate reductase". The Journal of Biological Chemistry 256 (16): 8510–8. PMID 7263666. 
  5. ^ Charalampous FC (Feb 1959). "Biochemical studies on inositol. V. Purification and properties of the enzyme that cleaves inositol to D-glucuronic acid". The Journal of Biological Chemistry 234 (2): 220–7. PMID 13630882. 
  6. ^ Cohen RA, MacGregor LC, Spokes KC, Silva P, Epstein FH (Oct 1990). "Effect of myo-inositol on renal Na-K-ATPase in experimental diabetes". Metabolism 39 (10): 1026–32. doi:10.1016/0026-0495(90)90161-5. PMID 2170818. 

External links[edit]