Inositol theory of bipolar disorder

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myo-Inositol is a sugar alcohol derived from glucose that serves as the basis of several secondary messengers inside eukaryotic cells including those inside the human body. In the human body inositol, especially in its monophosphate and triphosphate forms appears to play a role in mood stability. Consequently, many mood stabilisers alter the function of inositol monophosphate. Examples of mood stabilisers with this mechanism of action theorised or substantiated by the evidence include:

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  1. ^ Einat H, Kofman O, Itkin O, Lewitan RJ, Belmaker RH (1998). "Augmentation of lithium's behavioral effect by inositol uptake inhibitors". J Neural Transm 105 (1): 31–8. doi:10.1007/s007020050035. PMID 9588758. 
  2. ^ Dixon, John F.; Lowell E. Hokin (April 1997). "The antibipolar drug valproate mimics lithium in stimulating glutamate release and inositol 1,4,5-trisphosphate accumulation in brain cortex slices but not accumulation of inositol monophosphates and bisphosphates" (PDF). Proceedings of the National Academy of Sciences of the United States of America 94 (9): 4757–4760. doi:10.1073/pnas.94.9.4757. PMC 20797. PMID 9114064. 
  3. ^ Williams, Robin S. B.; Lili Cheng; Anne W. Mudge; Adrian J. Harwood (May 2002). "common mechanism of action for three mood-stabilizing drugs". Nature 417 (6886): 292–295. doi:10.1038/417292a. PMID 12015604.