Voyager receives its monthly datastream from Starfleet via the Pathfinder project, which has been helping Voyager find a way home from the Delta Quadrant. In the stream they find the programming for a hologram, and discover it is a simulation of Reginald Barclay, one of the Starfleet officers working on it. Holo-Barclay explains that Starfleet has found a way to return Voyager home through a geodesic fold between two red giants, but this will require special shield modifications and inoculations for the crew to survive the trip. The Doctor allows Holo-Barclay to use his mobile emitter as to supervise the work, and tries to be friends with him, but Holo-Barclay seems intent on his duty. Holo-Barclay even ignores the concerns the Doctor puts forward about the effectiveness of the inoculations, putting the Doctor on edge. The Doctor tells Captain Katheryn Janeway of his concerns, who orders a check of the Holo-Barclay program but finds nothing amiss. They continue to prepare the ship, while Holo-Barclay sends back reports included in Voyager 's datastream.
Meanwhile, on Earth, the real Barclay has attempted to send his hologram to Voyager with their datastream but finds it fails both times. He suspects that someone is intercepting the signal, but without proof, his supervisors orders him to take a vacation. While relaxing with Counselor Deanna Troi, Barclay laments his failure, as well as the fact his current girlfriend Leosa left him recently. In talking to her, Barclay comes to realize that Leosa left him the same day he tried to send his hologram, and suspects she might have been responsible. Barclay and Troi confront Leosa, who admits to having worked with the Ferengi to hijack Barclay's hologram and modify its programming before sending to Voyager for them to be able to steal Seven of Nine's Borg nanoprobes. Barclay is disappointed to learn that Leosa is only a dabu girl and not a teacher as she professed. They report this to Admiral Paris, who orders the Carolina to intercept the Ferengi ship according to Leosa's information.
En route, Barclay discovers that the Ferengi plan to bring Voyager to the Alpha Quadrant will work, but the process, with the given shield modifications and inoculations, will kill the crew, allowing the Ferengi freedom to steal the nanoprobes. With the Carolina unlikely to reach the Ferengi in time, Barclay tricks the Ferengi into believing that his is their Holo-Barclay. He claims that Voyager discovered that the shield modifications were designed to kill them and have instead reconfigured their shields to allow them to survive the journal through the fold and subsequently kill anyone they find on the opposite side. The Ferengi are frightened at this and begin to close down the fold. On the opposite side of the fold where Voyager waits, Holo-Barclay sees the fold closing and in a last-ditch attempt, steals Seven of Nine and attempts to enter the fold using an escape pod, but he is stopped in time.
With Voyager resuming course home and the situation with the modified Holo-Barclay settled, the real Barclay begins to rework his hologram with additional security features. Troi arrives and invites Barclay on a double date with her and William Riker, introduce him to a teacher friend that she knows.