Insilico Medicine is an American biotechnology company based in Rockville in Johns Hopkins University’s Emerging Technology Centers. The company combines genomics, big data analysis, and deep learning for the in silico drug discovery.
CEO Alex Zhavoronkov founded Insilico Medicine in 2014, as an alternative to animal testing for research and development programs in the pharmaceutical industry. By using artificial intelligence and deep-learning techniques, Insilico is able to analyze how a compound will affect cells and what drugs can be used to treat the cells in addition to possible side effects. Through its Pharma.AI division, the company provides machine learning services to different pharmaceutical, biotechnology, and skin care companies. Insilico is known for hiring mainly through hackathons such as their own molhack online hackathon.
The company has multiple collaborations in the applications of next-generation artificial intelligence technologies such as the generative adversarial networks and reinforcement learning to the generation of novel molecular structures with desired properties. In conjunction with Alan Aspuru-Guzik's group at Harvard, they have published an improved GAN architecture for molecular generation which combines GANs, reinforcement learning, and a differentiable neural computer.
Insilico's recent paper in Nature Communications describing the iPANDA dimensionality reduction algorithm included collaborators from 11 institutions. Some of the publications go beyond biotechnology and focus on organizational diversity and anti-racism. Insilico has also partnered with GSK, BioTime, Juvenescence, and quantum computer company YMK Photonics.
In 2017, Insilico was named one of the Top 5 AI companies by NVIDIA for its potential for social impact. Insilico also has R&D resources in Belgium, Russia, and the UK and hires talent through “hackathons” and other local competitions. By 2017, InSilico had raised $8.26 million in funding from investors including Deep Knowledge Ventures, JHU A-Level Capital, Jim Mellon, and Juvenescence. Investors announced in 2018 include WuXi AppTec, a Chinese integrated R&D services platform, Peter Diamandis’ BOLD Capital, and Pavilion Capital.
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- Kadurin, Artur; Nikolenko, Sergey; Khrabrov, Kuzma; Aliper, Alex; Zhavoronkov, Alex (5 September 2017). "druGAN: An Advanced Generative Adversarial Autoencoder Model for de Novo Generation of New Molecules with Desired Molecular Properties in Silico". Molecular Pharmaceutics. 14 (9): 3098–3104. doi:10.1021/acs.molpharmaceut.7b00346. PMID 28703000.
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- Ozerov, Ivan V.; Lezhnina, Ksenia V.; Izumchenko, Evgeny; Artemov, Artem V.; Medintsev, Sergey; Vanhaelen, Quentin; Aliper, Alexander; Vijg, Jan; Osipov, Andreyan N.; Labat, Ivan; West, Michael D.; Buzdin, Anton; Cantor, Charles R.; Nikolsky, Yuri; Borisov, Nikolay; Irincheeva, Irina; Khokhlovich, Edward; Sidransky, David; Camargo, Miguel Luiz; Zhavoronkov, Alex (16 November 2016). "In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development". Nature Communications. 7: ncomms13427. doi:10.1038/ncomms13427. PMC 5116087. PMID 27848968.
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