Institute of Genomics and Integrative Biology

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CSIR Institute of Genomics and Integrative Biology
Abbreviation CSIR-IGIB
Motto Genomics Knowledge Partner
Established 1977
Type Government organization
Purpose To translate concepts developed in basic biological research to commercially viable technologies for health care
Location
  • Sukhdev Vihar, Mathura Road,
    Delhi-110 025.
Director
Anurag Agrawal
Parent organization
Council of Scientific and Industrial Research
Website www.igib.res.in

CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB) is a scientific research institute devoted primarily to biological research. It is a part of Council of Scientific and Industrial Research (CSIR), India.[1]

The institute was founded in 1977 as the Center for Biochemical Technology with a primary focus on biochemical research, but has since shifted its research focus to integrative biology.

Location[edit]

The Institute has two campuses in Delhi. The North Campus is the oldest of the two campuses and is in the campus of Delhi University, on Mall Road opposite to Jubilee Hall. The new campus is in South Delhi, on Mathura Road at Sukhdev Vihar.

History[edit]

IGIB was established in 1977 as the Center for Biochemical Technology (CBT). The Functional Genomics Unit was established in 1998 with the focus shifting from chemical to genomics research. The institute was renamed "Institute of Genomics and Integrative Biology" in 2002.

Achievements[edit]

In 2009, a team at the institute sequenced the genome of the wild-type zebrafish, with about 1.7 billion base pairs. This made the fish, which is native to the Himalayan region, the first vertebrate to have its whole genome sequenced in India, as previously Indian scientists had only sequenced bacteria and plant genomes.[2][3]

In December 2009, scientists at IGIB performed the first re-sequencing of a human genome in India.[4][5][6] The Institute also collaborated on decoding the first Sri Lankan [7][8] genome and Malayasian genome.[9] The Institute is also a member of the Open Personal Genomics Consortium.[10]

Genomics of Rare Genetic Diseases[edit]

The institute has initiated a unique programme to use cutting edge genomic technologies to understand Rare genetic diseases in India and pioneering the application of genomics for Precision Medicine in clinics. One of the programmes which has been initiated on this front is Genomics for Understanding Rare Disease, India Alliance Network (GUaRDIAN).[11] GUaRDIAN is a large-scale collaborative network of clinicians from around India trying to use genomics in clinical practice, with the focussed aim to understand genetic structure of rare genetic diseases in India.

The consortium aims at using cutting edge genomics technology to enable identification of genetic variations in diseases and enable clinicians arrive at precise diagnosis for rare genetic disease. Apart from working closely with clinicians, the consortium aims to foster education, awareness and the widespread adoption of genomic technology in clinical settings, in addition to creating and disseminating the highest standards of genomic data generation and interpretation in India.[12]

In the few years, it has been able to work closely with clinicians in the network to be able to offer proof of principles for the application of Genomics for Precision Medicine.[13][14][15] A comprehensive programme for patient referral is also functional.[16]

Extension Centers (Branches)[edit]

The main IGIB campus is located at Mall Road, New Delhi near Delhi University North Campus. IGIB's alliance with the Biotech/Pharmaceuticals has led to its growth and setting up of two extension centers - one at South Delhi (IGIB Annex at TCGA, Okhla) and the other at Western Delhi at Naraina.

International Meetings[edit]

IGIB was a co-host of the 13th meeting of the Human Genome Organization (HUGO) in 2008, held at Hyderabad International Convention Centre.[17]

References[edit]

  1. ^ Council of Scientific and Industrial Research India Website Archived 2015-09-27 at the Wayback Machine..
  2. ^ Zebrafish Genome Webpage 'Institute of Genomics and Integrative Biology' (IGIB)
  3. ^ Decoding the Genome Mystery Indian Express, July 5, 2009.
  4. ^ Indian Scientists decode human genome Indian Express, December 10, 2009
  5. ^ * Patowary; et al. (2012). "Systematic analysis and functional annotation of variations in the genome of an Indian individual". Human Mutation. 33 (7): 1133–40. doi:10.1002/humu.22091. PMID 22461382.  [1]
  6. ^ Compilation of news articles and Press releases on Indian Genome, December 10, 2009
  7. ^ Sri Lankan genome
  8. ^ Dissanayake; et al. (2012). "The Sri Lankan Personal Genome Project: an overview". Sri Lanka Journal of Biomedical Informatics. 1 (2): 4–8.  [2]
  9. ^ [3]
  10. ^ OpenPGx Consortium
  11. ^ Genomics for Understanding Rare Diseases India Alliance Network (GUaRDIAN)
  12. ^ Exome Sequencing Analysis and Interpretation page on GUaRDIAN
  13. ^ Gupta; et al. (2015). "Whole-exome sequencing solves diagnostic dilemma in a rare case of sporadic acrokeratosis verruciformis". Journal of the European Academy of Dermatology and Venereology.  [4]
  14. ^ Gupta; et al. (2015). "Whole exome sequencing helps in accurate molecular diagnosis in siblings with a rare co-occurrence of paternally inherited 22q12 duplication and autosomal recessive non-syndromic ichthyosis". F1000 Research.  [5]
  15. ^ Vellarikkal; et al. (2014). "Exome sequencing reveals a novel mutation, p.L325H, in the KRT5 gene associated with autosomal dominant Epidermolysis Bullosa Simplex Koebner type in a large family from western India". Human Genome Variation. 1 (1): 14007.  [6]
  16. ^ Patient Referral Page Genomics for Understanding Rare Diseases India Alliance Network (GUaRDIAN)
  17. ^ HGM-2008 website.

External links[edit]