Integral monotopic protein

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Schematic representation of the different types of interaction between monotopic membrane proteins and the cell membrane: 1. interaction by an amphipathic α-helix parallel to the membrane plane (in-plane membrane helix) 2. interaction by a hydrophobic loop 3. interaction by a covalently bound membrane lipid (lipidation) 4. electrostatic or ionic interactions with membrane lipids (e.g. through a calcium ion)

Integral monotopic proteins, are permanently attached to the membrane from one side.[1]

Three-dimensional structures of the following integral monotopic proteins have been determined:

There are also structures of integral monotopic domains of transmembrane proteins: