Integrin, beta 5

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Integrin, beta 5
Symbols ITGB5 ; FLJ26658
External IDs OMIM147561 MGI96614 HomoloGene20511 ChEMBL: 2600 GeneCards: ITGB5 Gene
RNA expression pattern
PBB GE ITGB5 201124 at tn.png
PBB GE ITGB5 201125 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3693 16419
Ensembl ENSG00000082781 ENSMUSG00000022817
UniProt P18084 O70309
RefSeq (mRNA) NM_002213 NM_001145884
RefSeq (protein) NP_002204 NP_001139356
Location (UCSC) Chr 3:
124.76 – 124.9 Mb
Chr 16:
33.83 – 33.95 Mb
PubMed search [1] [2]

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.[1][2]


Integrin, beta 5 has been shown to interact with PTK2,[3] Annexin A5[4] and PAK4.[5]

Clinical significance[edit]


Elevated levels of ITGB5 have been found in patients suffering from autosomal dominant osteopetrosis type II, a rare disease of bones. [6]


  1. ^ McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem 265 (28): 17126–31. PMID 2211615. 
  2. ^ "Entrez Gene: ITGB5 integrin, beta 5". 
  3. ^ Eliceiri, Brian P; Puente Xose S; Hood John D; Stupack Dwayne G; Schlaepfer David D; Huang Xiaozhu Z; Sheppard Dean; Cheresh David A (Apr 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. (United States) 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263. PMID 11927607. 
  4. ^ Cardó-Vila, Marina; Arap Wadih; Pasqualini Renata (May 2003). "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell (United States) 11 (5): 1151–62. doi:10.1016/S1097-2765(03)00138-2. ISSN 1097-2765. PMID 12769841. 
  5. ^ Zhang, Hongquan; Li Zhilun; Viklund Eva-Karin; Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. (United States) 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN 0021-9525. PMC 2173231. PMID 12356872. 
  6. ^ Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology.". Lab Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069. 

Further reading[edit]

External links[edit]