Integrin, beta 5

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Aliases ITGB5, Integrin, beta 5, integrin subunit beta 5
External IDs MGI: 96614 HomoloGene: 20511 GeneCards: ITGB5
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ITGB5
Genomic location for ITGB5
Band 3q21.2 Start 124,761,948 bp[1]
End 124,901,418 bp[1]
RNA expression pattern
PBB GE ITGB5 201125 s at fs.png

PBB GE ITGB5 201124 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 3: 124.76 – 124.9 Mb Chr 3: 33.83 – 33.95 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.[5][6]


Integrin, beta 5 has been shown to interact with PTK2,[7] Annexin A5[8] and PAK4.[9]

Clinical significance[edit]


Elevated levels of ITGB5 have been found in patients suffering from autosomal dominant osteopetrosis type II, a rare disease of bones.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000082781 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022817 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. PMID 2211615. 
  6. ^ "Entrez Gene: ITGB5 integrin, beta 5". 
  7. ^ Eliceiri, Brian P; Puente Xose S; Hood John D; Stupack Dwayne G; Schlaepfer David D; Huang Xiaozhu Z; Sheppard Dean; Cheresh David A (Apr 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. United States. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263Freely accessible. PMID 11927607. 
  8. ^ Cardó-Vila, Marina; Arap Wadih; Pasqualini Renata (May 2003). "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell. United States. 11 (5): 1151–62. doi:10.1016/S1097-2765(03)00138-2. ISSN 1097-2765. PMID 12769841. 
  9. ^ Zhang, Hongquan; Li Zhilun; Viklund Eva-Karin; Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. United States. 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN 0021-9525. PMC 2173231Freely accessible. PMID 12356872. 
  10. ^ Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology". Lab Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069. 

Further reading[edit]

External links[edit]