Integrin alpha 4

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesITGA4, CD49D, IA4, integrin subunit alpha 4
External IDsOMIM: 192975 MGI: 96603 HomoloGene: 37364 GeneCards: ITGA4
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ITGA4
Genomic location for ITGA4
Band2q31.3Start181,457,202 bp[1]
End181,538,940 bp[1]
RNA expression pattern
PBB GE ITGA4 205884 at fs.png

PBB GE ITGA4 205885 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 181.46 – 181.54 MbChr 2: 79.26 – 79.33 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.


The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.[5]


CD49d has been shown to interact with LGALS8[6] and Paxillin.[7][8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115232 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027009 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)".
  6. ^ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell Sci. 113 (Pt 13): 2385–97. PMID 10852818.
  7. ^ Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH (November 2001). "Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding". J. Biol. Chem. 276 (44): 40903–9. doi:10.1074/jbc.M102665200. PMID 11533025.
  8. ^ Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH (June 2002). "A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration". J. Biol. Chem. 277 (23): 20887–94. doi:10.1074/jbc.M110928200. PMID 11919182.

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