Available structures PDB Ortholog search: PDBe RCSB
List of PDB id codes 1JV2, 1L5G, 1M1X, 1U8C, 3IJE, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4UM8, 4UM9 Identifiers Aliases , CD51, MSK8, VNRA, VTNR, integrin subunit alpha V ITGAV External IDs OMIM: 193210 MGI: 96608 HomoloGene: 20510 GeneCards: ITGAV
Gene location (Mouse) Chr. Chromosome 2 (mouse)  Band 2 D|2 49.33 cM Start 83,724,397 bp  End 83,806,916 bp  Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 2: 186.59 – 186.68 Mb Chr 2: 83.72 – 83.81 Mb PubMed search   Wikidata
Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.
Function [ edit ]
integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
Alpha V class integrins [ edit ]
In mammals the
integrins that include alpha-V are :
Clinical significance [ edit ]
Overexpression of the ITGAV gene is associated with progression and spread of
colorectal cancer, and prostate cancer. 
As a drug target [ edit ]
mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.
See also [ edit ]
References [ edit ]
^ a b c
GRCh38: Ensembl release 89: ENSG00000138448 - Ensembl, May 2017
^ a b c
GRCm38: Ensembl release 89: ENSMUSG00000027087 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS (June 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". The Journal of Clinical Investigation. 81 (6): 1993–8. doi: 10.1172/JCI113548. PMC . 442653 PMID 2454952.
"Entrez Gene: ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)".
^ a b
Hermann P, Armant M, Brown E, Rubio M, Ishihara H, Ulrich D, Caspary RG, Lindberg FP, Armitage R, Maliszewski C, Delespesse G, Sarfati M (February 1999). "The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23". The Journal of Cell Biology. 144 (4): 767–75. doi: 10.1083/jcb.144.4.767. PMC . 2132927 PMID 10037797.
Waisberg J, De Souza VL, Affonso Junior RJ, Silva SR, Denadai MV, Margeotto FB, De Souza CS, Matos D (2014). "Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer". Anticancer Res. 34 (10): 5599–607. PMID 25275062.
Cooper CR, Chay CH, Pienta KJ (2002). "The role of alpha(v)beta(3) in prostate cancer progression". Neoplasia. 4 (3): 191–4. doi: 10.1038/sj.neo.7900224. PMC . 1531692 PMID 11988838.
Élez E, Kocáková I, Höhler T, Martens UM, Bokemeyer C, Van Cutsem E, Melichar B, Smakal M, Csőszi T, Topuzov E, Orlova R, Tjulandin S, Rivera F, Straub J, Bruns R, Quaratino S, Tabernero J (January 2015). "Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial". Annals of Oncology. 26 (1): 132–40. doi: . 10.1093/annonc/mdu474 PMID 25319061.
Further reading [ edit ]
External links [ edit ]