Integrin beta 6

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesITGB6, AI1H, Integrin, beta 6, integrin subunit beta 6
External IDsOMIM: 147558 MGI: 96615 HomoloGene: 685 GeneCards: ITGB6
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ITGB6
Genomic location for ITGB6
Band2q24.2Start160,099,667 bp[1]
End160,200,313 bp[1]
RNA expression pattern
PBB GE ITGB6 208084 at fs.png

PBB GE ITGB6 208083 s at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 2: 160.1 – 160.2 MbChr 2: 60.6 – 60.72 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene.[5][6][7]

Clinical effects[edit]

Mutations in ITGB6 cause amelogenesis imperfecta.[8]


Integrin, beta 6 has been shown to interact with FHL2.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115221 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026971 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, Eccles M, Leung E, Watson JD (February 1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits". Immunogenetics. 35 (1): 58–61. doi:10.1007/bf00216629. PMID 1729173.
  6. ^ Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D (April 1994). "Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor". J Biol Chem. 269 (9): 6940–8. PMID 8120056.
  7. ^ "Entrez Gene: ITGB6 integrin, beta 6".
  8. ^ Wang, S. K.; Choi, M; Richardson, A. S.; Reid, B. M.; Lin, B. P.; Wang, S. J.; Kim, J. W.; Simmer, J. P.; Hu, J. C. (2014). "ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta". Human Molecular Genetics. 23 (8): 2157–63. doi:10.1093/hmg/ddt611. PMC 3959820. PMID 24305999.
  9. ^ Wixler, V; Geerts D; Laplantine E; Westhoff D; Smyth N; Aumailley M; Sonnenberg A; Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324.

Further reading[edit]

External links[edit]