Intercellular adhesion molecule

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Intercellular adhesion molecule (ICAM), N-terminal domain
PDB 1iam EBI.jpg
structure of the two amino-terminal domains of human intercellular adhesion molecule-1, icam-1
Pfam clanCL0011

In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events.[1] The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses. In addition, ICAMs may exist in soluble forms in human plasma, due to activation and proteolysis mechanisms at cell surfaces.

Mammalian intercellular adhesion molecules include:


  1. ^ Gahmberg CG, Tolvanen M, Kotovuori P (April 1997). "Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands". Eur. J. Biochem. 245 (2): 215–32. doi:10.1111/j.1432-1033.1997.00215.x. PMID 9151947.
This article incorporates text from the public domain Pfam and InterPro: IPR013768