Interferon regulatory factors
|Interferon regulatory factor transcription factor|
interferon regulatory factor-2 dna binding domain, nmr, minimized average structure
Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the interferon consensus sequence (ICS), which is located upstream of the interferon genes. The remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein.
- Paun A, Pitha PM (2007). "The IRF family, revisited". Biochimie 89 (6–7): 744–53. doi:10.1016/j.biochi.2007.01.014. PMC 2139905. PMID 17399883.
- Tsuneya Ikezu; Howard E. Gendelman (2008). Neuroimmune Pharmacology. Springer. pp. 213–. ISBN 978-0-387-72572-7. Retrieved 28 November 2010.
- Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ (December 1992). "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes". J. Biol. Chem. 267 (35): 25589–96. PMID 1460054.
- Interferon regulatory factors at the US National Library of Medicine Medical Subject Headings (MeSH)
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