Interleukin-10 receptor

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interleukin 10 receptor, alpha
Symbol IL10RA
Alt. symbols IL10R
Entrez 3587
HUGO 5964
OMIM 146933
RefSeq NM_001558
UniProt Q13651
Other data
Locus Chr. 11 q23
interleukin 10 receptor, beta
Symbol IL10RB
Alt. symbols CRFB4, D21S58, D21S66
Entrez 3588
HUGO 5965
OMIM 123889
RefSeq NM_000628
UniProt Q08334
Other data
Locus Chr. 21 q22.1-22.2

Interleukin-10 receptor is a type II cytokine receptor. The receptor is tetrameric, composed of 2α[1] and 2β[2] subunits. The α subunit is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells) whilst the β subunit is expressed ubiquitously.


  1. ^ Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW (1994). "Expression cloning and characterization of a human IL-10 receptor". J. Immunol. 152 (4): 1821–9. PMID 8120391. 
  2. ^ Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S (1997). "Identification and functional characterization of a second chain of the interleukin-10 receptor complex". EMBO J. 16 (19): 5894–903. doi:10.1093/emboj/16.19.5894. PMC 1170220Freely accessible. PMID 9312047. 

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