Interleukin-18 receptor

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interleukin 18 receptor 1
Symbol IL18R1
Alt. symbols IL1RRP, IL-1Rrp, CD218a
Entrez 8809
HUGO 5988
OMIM 604494
RefSeq NM_003855
UniProt Q13478
Other data
Locus Chr. 2 q12
interleukin 18 receptor accessory protein
Symbol IL18RAP
Alt. symbols AcPL, CD218b
Entrez 8807
HUGO 5989
OMIM 604509
RefSeq NM_003853
UniProt O95256
Other data
Locus Chr. 2 p24.3-24.1

The interleukin-18 receptor (IL-18R) is an interleukin receptor of the immunoglobulin superfamily.[1][2] IL-18R is a heteromeric complex of alpha- and beta-chains encoded by the genes IL18R1 and IL18RAP respectively.

Endometrial IL-18 receptor mRNA and the ratio of IL-18 binding protein to interleukin 18 are significantly increased in adenomyosis patients in comparison to normal people, indicating a role in its pathogenesis.[3]


  1. ^ Sergi B, Penttila I (2004). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents. 18 (1): 55–61. PMID 15323361. 
  2. ^ Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T (2003). "IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction". J. Immunol. 170 (11): 5571–7. doi:10.4049/jimmunol.170.11.5571. PMID 12759435. 
  3. ^ Huang, H.; Yu, H.; Chan, S.; Lee, C.; Wang, H.; Soong, Y. (2010). "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Fertility and Sterility. 94 (1): 33–39. doi:10.1016/j.fertnstert.2009.01.132. PMID 19394601. 

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