Interleukin-3 receptor

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interleukin 3 receptor, alpha
Identifiers
Symbol IL3RA
Alt. symbols CD123
HUGO 6012
OMIM 308385
Other data
Locus Chr. X p22.3
interleukin 3 receptor, Y-Chromosomal
Identifiers
Symbol IL3RA
Alt. symbols IL3RY, IL3RAY
Entrez 3563
HUGO 6012
OMIM 430000
Other data
Locus Chr. Y p11.3

The interleukin-3 receptor (also known as CD123 antigen) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.

The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.

The receptor belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CD131) subunit.

The gene for the alpha subunit is 40 kilobases long and has 12 exons.

Cell types and function[edit]

The receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines. It can be found on basophils and pDCs as well as some cDCs among peripheral blood mononuclear cells.

CD123 is expressed across acute myeloid leukemia (AML) subtypes, including leukemic stem cells.[1]

Possible drug target[edit]

An experimental antibody-drug conjugate SGN-CD123A targets CD123 as a possible treatment for AML.[1]

References[edit]

External links[edit]