Interleukin-4 receptor

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IL4R
Protein IL4R PDB 1iar.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases IL4R, CD124, IL-4RA, IL4RA, Interleukin-4 receptor, interleukin 4 receptor
External IDs MGI: 105367 HomoloGene: 7784 GeneCards: 3566
RNA expression pattern
PBB GE IL4R 203233 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000418
NM_001008699
NM_001257406
NM_001257407
NM_001257997

NM_001008700
NM_010557

RefSeq (protein)

NP_000409.1
NP_001244335.1
NP_001244336.1

NP_001008700.1

Location (UCSC) Chr 16: 27.31 – 27.36 Mb Chr 7: 125.55 – 125.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse
Interleukin-4 receptor alpha chain, N-terminal
PDB 1iar EBI.jpg
interleukin-4 / receptor alpha chain complex
Identifiers
Symbol IL4Ra_N
Pfam PF09238
InterPro IPR015319
SCOP 1iar
SUPERFAMILY 1iar

The interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.

Function[edit]

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitis, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.[1]

The binding of IL-4 or IL-13 to the IL-4 receptor on the surface of macrophages results in the alternative activation of those macrophages. Alternatively activated macrophages (AAMΦ) downregulate inflammatory mediators such as IFNγ during immune responses, particularly with regards to helminth infections.[2]

Interactions[edit]

Interleukin-4 receptor has been shown to interact with SHC1.[3][4]

Structure[edit]

The N-terminal (extracellular) portion of interleukin-4 receptor is related in overall topology to fibronectin type III modules and folds into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.[5]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: IL4R interleukin 4 receptor". 
  2. ^ Tundup S, Srivastava L, Harn DA (April 2012). "Polarization of host immune responses by helminth-expressed glycans". Ann. N. Y. Acad. Sci. 1253: E1–E13. doi:10.1111/j.1749-6632.2012.06618.x. PMID 22974465. 
  3. ^ Ikizawa K, Yanagihara Y (February 2000). "Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line". Biochem. Biophys. Res. Commun. 268 (1): 54–9. doi:10.1006/bbrc.2000.2080. PMID 10652211. 
  4. ^ Kashiwada M, Giallourakis CC, Pan PY, Rothman PB (December 2001). "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation". J. Immunol. 167 (11): 6382–7. doi:10.4049/jimmunol.167.11.6382. PMID 11714803. 
  5. ^ Hage T, Sebald W, Reinemer P (April 1999). "Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface". Cell 97 (2): 271–81. doi:10.1016/S0092-8674(00)80736-9. PMID 10219247. 

Further reading[edit]

External links[edit]

This article incorporates text from the public domain Pfam and InterPro IPR015319