Interleukin-9 receptor

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IL9R
Identifiers
Aliases IL9R, CD129, IL-9R, interleukin 9 receptor
External IDs MGI: 96564 HomoloGene: 37591 GeneCards: 3581
RNA expression pattern
PBB GE IL9R 208164 s at tn.png

PBB GE IL9R 214950 at tn.png

PBB GE IL9R 217212 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002186
NM_176786

NM_001134458
NM_008374

RefSeq (protein)

NP_002177.2
NP_789743.2

NP_032400.1

Location (UCSC) Chr X: 156 – 156.01 Mb Chr 11: 32.19 – 32.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene.[3]

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses.  This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Interactions[edit]

Interleukin-9 receptor has been shown to interact with YWHAZ.[4]

See also[edit]

References[edit]

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.