Interleukin-9 receptor

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Interleukin 9 receptor
Symbols IL9R ; CD129; IL-9R
External IDs OMIM300007 MGI96564 HomoloGene37591 GeneCards: IL9R Gene
RNA expression pattern
PBB GE IL9R 208164 s at tn.png
PBB GE IL9R 214950 at tn.png
PBB GE IL9R 217212 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3581 16199
Ensembl ENSG00000124334 ENSMUSG00000020279
UniProt Q01113 Q01114
RefSeq (mRNA) NM_002186 NM_001134458
RefSeq (protein) NP_002177 NP_001127930
Location (UCSC) Chr X:
156 – 156.01 Mb
Chr 11:
32.19 – 32.2 Mb
PubMed search [1] [2]

Interleukin 9 receptor (IL9R) also known as CD129 (Cluster of Differentiation 129) is a type I cytokine receptor. IL9R also denotes its human gene.[1]

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses.  This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]


Interleukin-9 receptor has been shown to interact with YWHAZ.[2]

See also[edit]


  1. ^ a b "Entrez Gene: IL9R interleukin 9 receptor". 
  2. ^ Sliva, D; Gu M; Zhu Y X; Chen J; Tsai S; Du X; Yang Y C (February 2000). "14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor". Biochem. J. (ENGLAND). 345 Pt 3 (3): 741–7. doi:10.1042/0264-6021:3450741. ISSN 0264-6021. PMC 1220812. PMID 10642536. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.