Interleukin 11 receptor alpha subunit

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Interleukin 11 receptor, alpha
Symbols IL11RA ; CRSDA
External IDs OMIM600939 HomoloGene88705 ChEMBL: 2050 GeneCards: IL11RA Gene
Species Human Mouse
Entrez 3590 16157
Ensembl ENSG00000137070 ENSMUSG00000073889
UniProt Q14626 Q64385
RefSeq (mRNA) NM_001142784 NM_001163401
RefSeq (protein) NP_001136256 NP_001156873
Location (UCSC) Chr 9:
34.65 – 34.66 Mb
Chr 4:
41.7 – 41.77 Mb
PubMed search [1] [2]

Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.[1]

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.[1]


Further reading[edit]