Interleukin 11 receptor alpha subunit

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IL11RA
Identifiers
Aliases IL11RA, CRSDA, Interleukin 11 receptor alpha subunit, interleukin 11 receptor subunit alpha
External IDs MGI: 3780172 HomoloGene: 88705 GeneCards: IL11RA
Gene location (Human)
Chromosome 9 (human)
Chr. Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for IL11RA
Genomic location for IL11RA
Band No data available Start 34,650,702 bp[1]
End 34,661,892 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142784
NM_004512
NM_147162

NM_001100596

RefSeq (protein)

NP_001136256

NP_001092818
NP_034680

Location (UCSC) Chr 9: 34.65 – 34.66 Mb Chr 9: 42.16 – 42.17 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.[5]

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.[5]

References[edit]

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