Interleukin 11 receptor alpha subunit

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IL11RA
Identifiers
AliasesIL11RA, CRSDA, Interleukin 11 receptor alpha subunit, interleukin 11 receptor subunit alpha
External IDsOMIM: 600939 MGI: 109123 HomoloGene: 88705 GeneCards: IL11RA
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for IL11RA
Genomic location for IL11RA
Band9p13.3Start34,650,702 bp[1]
End34,661,892 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142784
NM_004512
NM_147162

NM_010550

RefSeq (protein)

NP_001136256

NP_001092818

Location (UCSC)Chr 9: 34.65 – 34.66 MbChr 4: 42.66 – 42.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.[5]

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137070 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078735 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: IL11RA interleukin 11 receptor, alpha".

Further reading[edit]