Interleukin 1 receptor, type I

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Interleukin 1 receptor, type I
Protein IL1R1 PDB 1g0y.png
PDB rendering based on 1g0y.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IL1R1 ; CD121A; D2S1473; IL-1R-alpha; IL1R; IL1RA; P80
External IDs OMIM147810 MGI96545 HomoloGene677 ChEMBL: 1959 GeneCards: IL1R1 Gene
RNA expression pattern
PBB GE IL1R1 215561 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3554 16177
Ensembl ENSG00000115594 ENSMUSG00000026072
UniProt P14778 P13504
RefSeq (mRNA) NM_000877 NM_001123382
RefSeq (protein) NP_000868 NP_001116854
Location (UCSC) Chr 2:
102.06 – 102.18 Mb
Chr 1:
40.23 – 40.32 Mb
PubMed search [1] [2]

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.[1]

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.[1]


Interleukin 1 receptor, type I has been shown to interact with PIK3R1,[2] Myd88[3][4] and IL1RAP.[5]

See also[edit]


  1. ^ a b "Entrez Gene: IL1R1 interleukin 1 receptor, type I". 
  2. ^ Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. (UNITED STATES) 272 (46): 29167–73. doi:10.1074/jbc.272.46.29167. ISSN 0021-9258. PMID 9360994. 
  3. ^ Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. (ENGLAND) 2 (6): 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325. 
  4. ^ Muzio, M; Ni J; Feng P; Dixit V M (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science (UNITED STATES) 278 (5343): 1612–5. doi:10.1126/science.278.5343.1612. ISSN 0036-8075. PMID 9374458. 
  5. ^ Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (24): 12829–32. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.