Interleukin 1 receptor, type II

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Interleukin 1 receptor, type II
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IL1R2 ; CD121b; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2; IL1R2c; IL1RB
External IDs OMIM147811 MGI96546 HomoloGene7783 GeneCards: IL1R2 Gene
RNA expression pattern
PBB GE IL1R2 205403 at tn.png
PBB GE IL1R2 211372 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7850 16178
Ensembl ENSG00000115590 ENSMUSG00000026073
UniProt P27930 P27931
RefSeq (mRNA) NM_001261419 NM_010555
RefSeq (protein) NP_001248348 NP_034685
Location (UCSC) Chr 2:
101.99 – 102.03 Mb
Chr 1:
40.07 – 40.13 Mb
PubMed search [1] [2]

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.


The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.[1]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.