Interleukin 1 receptor, type II

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesIL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, Interleukin 1 receptor, type II, interleukin 1 receptor type 2
External IDsOMIM: 147811 MGI: 96546 HomoloGene: 7783 GeneCards: IL1R2
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for IL1R2
Genomic location for IL1R2
Band2q11.2Start101,991,960 bp[1]
End102,028,544 bp[1]
RNA expression pattern
PBB GE IL1R2 211372 s at fs.png

PBB GE IL1R2 205403 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 101.99 – 102.03 MbChr 1: 40.07 – 40.13 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.


The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. IL-1R2 protein also interacts non-productively with the second component of the signalling IL-1 receptor, namely IL-1RAcP,[5] and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography.[6] Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.[7]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115590 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026073 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lang, D; Knop, J; Wesche, H; Raffetseder, U; Kurrie, R; Boraschi, D; Martin, MU (1998). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness". Journal of Immunology. 161 (12): 6871–6877.
  6. ^ Wang, Dongli; Zhang, Senyan; Li, Liang; Liu, Xi; Mei, Kunrong; Wang, Xinquan (29 August 2010). "Structural insights into the assembly and activation of IL-1β with its receptors". Nature Immunology. 11 (10): 905–911. doi:10.1038/ni.1925.
  7. ^ "Entrez Gene: IL1R2 interleukin 1 receptor, type II".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.