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AliasesIL1RL2, IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2, interleukin 1 receptor like 2
External IDsMGI: 1913107 HomoloGene: 2860 GeneCards: IL1RL2
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for IL1RL2
Genomic location for IL1RL2
Band2q12.1Start102,187,006 bp[1]
End102,240,002 bp[1]
RNA expression pattern
PBB GE IL1RL2 208038 at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 2: 102.19 – 102.24 MbChr 1: 40.32 – 40.37 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene.[5][6][7][8]

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115598 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070942 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA (Dec 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". J Neuroimmunol. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719.
  6. ^ Dale M, Nicklin MJ (Jun 1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.
  7. ^ Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA (Jul 2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". Journal of Immunology. 167 (3): 1440–6. doi:10.4049/jimmunol.167.3.1440. PMID 11466363.
  8. ^ a b "Entrez Gene: IL1RL2 interleukin 1 receptor-like 2".

Further reading[edit]