Interleukin 20 is a protein that in humans is encoded by the IL20 gene. [1 ]
Function [ edit ]
The protein encoded by this gene is a cytokine structurally related to
interleukin 10 (IL-10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 ( STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [1 ]
Interleukin-20 (IL-20) is a protein belonging to the
IL-10 family of cytokines. IL-20 is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL-20 also causes cell expansion of multipotential hematopoietic progenitor cells. [2 ]
Anti IL-20 [ edit ]
Anti-IL-20 monoclonal antibodies have been researched as clinical candidates for the treatment or prevention of psoriasis, rheumatoid arthritis, atherosclerosis, and stroke.
References [ edit ]
^ a b "Entrez Gene: Interleukin 20".
^ Rich BE, Kupper TS (August 2006). "Interleukin 20". Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 5 (3): 243–250. doi: 10.2174/187152306778017683.
^ Hsu, YH; Chen, WY; Chan, CH; Wu first4=CH; Sun, ZJ=; Chang first6=MS (29 Aug 2011). "Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss.". J Exp Med. 208 (9): 1849–61. doi: 10.1084/jem.20102234.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.