Interleukin 25

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Interleukin 25
Symbols IL25 ; IL17E
External IDs OMIM605658 MGI2155888 HomoloGene15429 GeneCards: IL25 Gene
RNA expression pattern
PBB GE IL25 220971 at tn.png
More reference expression data
Species Human Mouse
Entrez 64806 140806
Ensembl ENSG00000166090 ENSMUSG00000040770
UniProt Q9H293 Q8VHH8
RefSeq (mRNA) NM_022789 NM_080729
RefSeq (protein) NP_073626 NP_542767
Location (UCSC) Chr 14:
23.37 – 23.38 Mb
Chr 14:
54.93 – 54.94 Mb
PubMed search [1] [2]

Interleukin-25 (IL-25) – also known as interleukin-17E (IL-17E)[1] – is a protein that in humans is encoded by the IL25 gene.[2][3][4]


IL-25 is a cytokine that shares the sequence similarity with IL17. This cytokine can induce NF-κB activation, and stimulate the production of IL8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17RB. Studies of the similar gene in mice suggested that this cytokine may be a proinflammatory cytokine favoring Th2-type immune response. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[4]

IL-25 is a cytokine that belongs to the IL-17 cytokine family and is secreted by type 2 helper T cells (Th2) and mast cells.[5][6]

Clinical significance[edit]

IL-25 induces the production of other cytokines, including IL-4, IL-5 and IL-13 in multiple tissues, which stimulate the expansion of eosinophils. This cytokine is an important molecule controlling immunity of the gut[7] and has been implicated in chronic inflammation associated with the gastrointestinal tract. IL-25 can kill some types of breast cancer cells.[8]

Further, the IL-25 gene has been identified in a chromosomal region associated with autoimmune diseases of the gut such as inflammatory bowel disease (IBD), although no direct evidence suggests that IL-25 plays any role in this disease.[9]


  1. ^ Product reference for IL-17E
  2. ^ Lee J, Ho WH, Maruoka M, Corpuz RT, Baldwin DT, Foster JS, Goddard AD, Yansura DG, Vandlen RL, Wood WI, Gurney AL (Mar 2001). "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1". J Biol Chem 276 (2): 1660–4. doi:10.1074/jbc.M008289200. PMID 11058597. 
  3. ^ Fort MM, Cheung J, Yen D, Li J, Zurawski SM, Lo S, Menon S, Clifford T, Hunte B, Lesley R, Muchamuel T, Hurst SD, Zurawski G, Leach MW, Gorman DM, Rennick DM (Dec 2001). "IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo". Immunity 15 (6): 985–95. doi:10.1016/S1074-7613(01)00243-6. PMID 11754819. 
  4. ^ a b "Entrez Gene: IL25 interleukin 25". 
  5. ^ Ikeda K, Nakajima H, Suzuki K, Kagami S, Hirose K, Suto A, Saito Y, Iwamoto I (May 2003). "Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation". Blood 101 (9): 3594–6. doi:10.1182/blood-2002-09-2817. PMID 12511410. 
  6. ^ The HGNC site for IL-25
  7. ^ Owyang AM, Zaph C, Wilson EH, Guild KJ, McClanahan T, Miller HR, Cua DJ, Goldschmidt M, Hunter CA, Kastelein RA, Artis D (April 2006). "Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract". J. Exp. Med. 203 (4): 843–9. doi:10.1084/jem.20051496. PMC 1800834. PMID 16606667. 
  8. ^ Furuta S, Jeng YM, Zhou L, Huang L, Kuhn I, Bissell MJ, Lee WH (April 2011). "IL-25 Causes Apoptosis of IL-25R-Expressing Breast Cancer Cells Without Toxicity to Nonmalignant Cells". Sci Transl Med 3 (78): 78ra31. doi:10.1126/scitranslmed.3001374. PMC 3199022. PMID 21490275. Lay summaryGenetic Engineering & Biotechnology News. 
  9. ^ Büning C, Genschel J, Weltrich R, Lochs H, Schmidt H (October 2003). "The interleukin-25 gene located in the inflammatory bowel disease (IBD) 4 region: no association with inflammatory bowel disease". Eur. J. Immunogenet. 30 (5): 329–33. doi:10.1046/j.1365-2370.2003.00411.x. PMID 14641539. 

Further reading[edit]