Interleukin 26

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Interleukin 26
Symbols IL26 ; AK155; IL-26
External IDs OMIM605679 HomoloGene81862 GeneCards: IL26 Gene
Species Human Mouse
Entrez 55801 n/a
Ensembl ENSG00000111536 n/a
UniProt Q9NPH9 n/a
RefSeq (mRNA) NM_018402 n/a
RefSeq (protein) NP_060872 n/a
Location (UCSC) Chr 12:
68.2 – 68.23 Mb
PubMed search [1] n/a

Interleukin-26 (IL-26) is a protein that in humans is encoded by the IL26 gene.[1][2][3]

IL-26 is a 171-amino acid protein, which is similar in amino acid sequence to interleukin 10. It was originally called AK155 and is composed of a signal sequence, 6 helices, and 4 conserved cysteine residues. IL-26 is expressed in certain herpesvirus-transformed T cells but not in primary stimulated T cells.[2] IL-26 signals through a receptor complex comprising two distinct proteins called IL-20 receptor 1 and IL-10 receptor 2.[4] By signaling through this receptor complex, IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3, which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule on the surface of epithelial cells.[5]


  1. ^ "Entrez Gene: interleukin 26". 
  2. ^ a b Knappe A, Hör S, Wittmann S, Fickenscher H (April 2000). "Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri". J. Virol. 74 (8): 3881–7. doi:10.1128/JVI.74.8.3881-3887.2000. PMC 111897. PMID 10729163. 
  3. ^ Goris A, Marrosu MG, Vandenbroeck K (August 2001). "Novel polymorphisms in the IL-10 related AK155 gene (chromosome 12q15)". Genes Immun. 2 (5): 284–6. doi:10.1038/sj.gene.6363772. PMID 11528524. 
  4. ^ Sheikh F, Baurin VV, Lewis-Antes A, Shah NK, Smirnov SV, Anantha S, Dickensheets H, Dumoutier L, Renauld JC, Zdanov A, Donnelly RP, Kotenko SV (February 2004). "Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2". J. Immunol. 172 (4): 2006–10. doi:10.4049/jimmunol.172.4.2006. PMID 14764663. 
  5. ^ Hör S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, Renauld J, de Waal Malefyt R, Fickenscher H (2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains". J Biol Chem 279 (32): 33343–51. doi:10.1074/jbc.M405000200. PMID 15178681. 

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