Interleukin 29

From Wikipedia, the free encyclopedia
Jump to: navigation, search
IFNL1
Protein IL29 PDB 3OG4.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases IFNL1, IL-29, IL29, interferon, lambda 1
External IDs OMIM: 607403 HomoloGene: 131189 GeneCards: 282618
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_172140

n/a

RefSeq (protein)

NP_742152.1

n/a

Location (UCSC) Chr 19: 39.3 – 39.3 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Interleukin-29 (IL-29) is a protein that in humans is encoded by the IL29 gene that resides on chromosome 19.[1][2]

IL-29 is a member of the helical cytokine family and is a type III interferon.[3] It is also known as IFNλ1 and is highly similar in amino acid sequence to the IL-28, the other type III interferon. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL29 is not present in the mouse genome.

References[edit]

  1. ^ "Entrez Gene: interleukin 29 (interferon". 
  2. ^ Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM (January 2003). "IL-28, IL-29 and their class II cytokine receptor IL-28R". Nat. Immunol. 4 (1): 63–8. doi:10.1038/ni873. PMID 12469119. 
  3. ^ Vilcek J (January 2003). "Novel interferons". Nat. Immunol. 4 (1): 8–9. doi:10.1038/ni0103-8. PMID 12496969. 

Further reading[edit]