Interleukin 29

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Interferon, lambda 1
Protein IL29 PDB 3OG4.png
Rendering based on PDB 3OG4​.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IFNL1 ; IL-29; IL29
External IDs OMIM607403 HomoloGene131189 GeneCards: IFNL1 Gene
Species Human Mouse
Entrez 282618 n/a
Ensembl ENSG00000182393 n/a
UniProt Q8IU54 n/a
RefSeq (mRNA) NM_172140 n/a
RefSeq (protein) NP_742152 n/a
Location (UCSC) Chr 19:
39.3 – 39.3 Mb
PubMed search [1] n/a

Interleukin-29 (IL-29) is a protein that in humans is encoded by the IL29 gene that resides on chromosome 19.[1][2]

IL-29 is a member of the helical cytokine family and is a type III interferon.[3] It is also known as IFNλ1 and is highly similar in amino acid sequence to the IL-28, the other type III interferon. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL29 is not present in the mouse genome.


  1. ^ "Entrez Gene: interleukin 29 (interferon". 
  2. ^ Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM (January 2003). "IL-28, IL-29 and their class II cytokine receptor IL-28R". Nat. Immunol. 4 (1): 63–8. doi:10.1038/ni873. PMID 12469119. 
  3. ^ Vilcek J (January 2003). "Novel interferons". Nat. Immunol. 4 (1): 8–9. doi:10.1038/ni0103-8. PMID 12496969. 

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