Interleukin 29

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Protein IL28RA PDB 3OG4.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases IFNL1, IL-29, IL29, interferon, lambda 1, interferon lambda 1
External IDs OMIM: 607403 HomoloGene: 131189 GeneCards: IFNL1
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 39.3 – 39.3 Mb n/a
PubMed search [1] n/a
View/Edit Human

Interleukin-29 (IL-29) is a protein that in humans is encoded by the IL29 gene that resides on chromosome 19.[2][3]

IL-29 is a member of the helical cytokine family and is a type III interferon.[4] It is also known as IFNλ1 and is highly similar in amino acid sequence to the IL-28, the other type III interferon. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL29 is not present in the mouse genome.


  1. ^ "Human PubMed Reference:". 
  2. ^ "Entrez Gene: interleukin 29 (interferon". 
  3. ^ Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM (January 2003). "IL-28, IL-29 and their class II cytokine receptor IL-28R". Nat. Immunol. 4 (1): 63–8. doi:10.1038/ni873. PMID 12469119. 
  4. ^ Vilcek J (January 2003). "Novel interferons". Nat. Immunol. 4 (1): 8–9. doi:10.1038/ni0103-8. PMID 12496969. 

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