Interleukin 30

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
IL27
Identifiers
AliasesIL27, IL-27, IL-27A, IL27A, IL27p28, IL30, p28, Interleukin 30, IL-30, interleukin 27
External IDsMGI: 2384409 HomoloGene: 17087 GeneCards: IL27
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for IL27
Genomic location for IL27
Band16p12.1-p11.2Start28,499,362 bp[1]
End28,512,051 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145659

NM_145636

RefSeq (protein)

NP_663634

NP_663611

Location (UCSC)Chr 16: 28.5 – 28.51 MbChr 7: 126.59 – 126.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin-30 (IL-30) is a protein with a molecular weight of 28 kilodaltons, which forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus is sometimes called IL27-p28. The other chain of IL-27 is a molecule called Epstein-Barr induced gene-3 (EBI3). IL-30 is a member of the long-chain, 4-helix bundle family of cytokines, making it structurally similar to IL-6.[5] This gene for this molecule is now officially called IL-27 under HGNC guidelines.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197272 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044701 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA (June 2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity. 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660. 
  6. ^ http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157