Interleukin 31

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IL31
Identifiers
Aliases IL31, IL-31, interleukin 31
External IDs OMIM: 609509 HomoloGene: 88541 GeneCards: 386653
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001014336

n/a

RefSeq (protein)

NP_001014358.1

n/a

Location (UCSC) Chr 12: 122.17 – 122.17 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Interleukin-31 (IL-31) is a protein that in humans is encoded by the IL31 gene.[1][2]

Function[edit]

IL-31 is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). The structure of IL-31 places it in the IL-6 family of cytokines. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells.[1]

Clinical significance[edit]

IL-31 is believed to play a role in inflammation of the skin.[2]

References[edit]

  1. ^ a b "Entrez Gene: interleukin 31". 
  2. ^ a b Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA (July 2004). "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice". Nat. Immunol. 5 (7): 752–60. doi:10.1038/ni1084. PMID 15184896.