Interleukin 31

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Interleukin 31
Symbols IL31 ; IL-31
External IDs OMIM609509 HomoloGene88541 GeneCards: IL31 Gene
Species Human Mouse
Entrez 386653 n/a
Ensembl ENSG00000204671 n/a
UniProt Q6EBC2 n/a
RefSeq (mRNA) NM_001014336 n/a
RefSeq (protein) NP_001014358 n/a
Location (UCSC) Chr 12:
122.17 – 122.17 Mb
PubMed search [1] n/a

Interleukin-31 also known as IL-31 is a protein that in humans is encoded by the IL31 gene.[1][2]


IL-31 is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). The structure of IL-31 places it in the IL-6 family of cytokines. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells.[1]

Clinical significance[edit]

IL-31 is believed to play a role in inflammation of the skin.[2]


  1. ^ a b "Entrez Gene: interleukin 31". 
  2. ^ a b Dillon SR, Sprecher C, Hammond A, Bilsborough J, Rosenfeld-Franklin M, Presnell SR, Haugen HS, Maurer M, Harder B, Johnston J, Bort S, Mudri S, Kuijper JL, Bukowski T, Shea P, Dong DL, Dasovich M, Grant FJ, Lockwood L, Levin SD, LeCiel C, Waggie K, Day H, Topouzis S, Kramer J, Kuestner R, Chen Z, Foster D, Parrish-Novak J, Gross JA (July 2004). "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice". Nat. Immunol. 5 (7): 752–60. doi:10.1038/ni1084. PMID 15184896.