International Prognostic Scoring System

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The International Prognostic Scoring System (IPSS), published in 1997, is used by many doctors to help assess the severity of a patient's myelodysplastic syndrome (MDS). Based on the IPSS score, the patient's history, and his/her personal observations, the physician will design a treatment plan to address the MDS.

The IPSS uses three "prognostic indicators" to develop a "score" which may be useful in understanding how the MDS may progress:

Each indicator is rated according to its severity and the ratings are combined into a "score."

Scores are sorted into one of four risk categories:

  • low
  • intermediate-1
  • intermediate-2
  • high

The two lower categories can be further described as the lower risk group while the two upper categories can be further described as the higher risk group.[1]

A revised IPSS, IPSS-R was published in 2012. IPSS-R is more refined in its prognostic precision and includes five instead of four prognostic groups.