International Society for Extracellular Vesicles

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International Society for Extracellular Vesicles
Founded2011
TypeProfessional organization
FocusExtracellular vesicles, exosomes
Area served
Worldwide
MethodConferences, publications, education
Members
>1000
Key people
Andrew Hill (president), Jan Lötvall (past president)
Websiteisev.org

The International Society for Extracellular Vesicles (ISEV) is an international scientific organization that focuses on the study of extracellular vesicles (EVs),[1] including exosomes, microvesicles, oncosomes, and other membrane-bound particles that are released from cells. Established in 2011, the society is a non-profit entity and a 501(c)(3) corporation in the United States. ISEV is governed by an executive committee. The current president of ISEV (2016-2018) is Andrew Hill; the founding president (2011-2016) is Jan Lötvall.[2] The society publishes the Journal of Extracellular Vesicles, the only journal devoted to the topic.

Meetings[edit]

As part of its mission to promote scientific research and education, ISEV hosts an annual meeting and educational event as well as numerous workshops on defined EV-related topics. ISEV also co-sponsors or endorses related events. Following an organisational meeting in Paris, France in 2011, chaired by EV pioneers Graça Raposo and Clotilde Théry)[3], the first annual meeting of ISEV was held in Gothenburg, Sweden, in 2012.[4] Subsequent meeting were in Boston, United States (2013),[5][6][7] Rotterdam, Netherlands (2014 and 2016), Washington, DC, (2015, with an Education Day in collaboration with the Extracellular RNA Communication Consortium of the US National Institutes of Health[8][9]), Toronto (2017), and Barcelona, Spain (2018).[10] The first annual meeting in the Asia-Pacific region will be held in Kyoto, Japan in 2019,[11] followed by a 2020 meeting Philadelphia, United States.[12]

Workshops and scientific seminars[edit]

ISEV workshops began with a meeting on extracellular RNA (New York City, 2012),[13][14][15] and continued to included one to two meetings per year. Topics covered have included EV diagnostics and therapeutics,[16][17] isolation and characterization,[18] proteomics and lipidomics,[19] EV-associated RNA,[20][21] Application of Therapeutic EVs in the Patient,[22] Membranes and Extracellular Vesicles,[23] and more.[24][25]

Endorsed or co-sponsored events[edit]

ISEV has directly or indirectly supported EV-related events around the world. These include, but are not limited to, an EV therapeutics meeting in Providence, Rhode Island, United States (2014), [26] meetings of the UK, French, and Spanish and Portuguese EV Societies (GEIVEX), the European Molecular Biology Laboratory (EMBL) Advanced Course on "EV Purification, Identification and Translation", the Keystone Symposium "Exosomes/Microvesicles: Novel Mechanisms of Cell-Cell Communication" (2016 and 2018)[27], the Gordon Research Conference on "Biologic Effects and Therapeutic Potential of Extracellular Vesicles" (2016 and 2018)[28] a Cold Spring Harbor Asia Meeting, "Biology & Function of Extracellular Vesicles: Exosomes, Microvesicles & Beyond" (2016),[29] and many others.

Journal of Extracellular Vesicles and standardization initiatives[edit]

To disseminate research in the field, ISEV established the peer-reviewed and open access Journal of Extracellular Vesicles (J Extracell Vesicles or JEV) in 2012.[30] Originally part of Co-Action Publishing, JEV has been published since 2016 by Taylor & Francis. JEV is included in PubMed and Scopus and is now tracked by Clarivate Analytics for assignment of Journal Impact Factor (IF) in 2019. The editors-in-chief are Clotilde Théry (Institut Curie), Peter Quesenberry (Brown University) and Yong Song Gho (Pohang University of Science and Technology), and the founding editor was Jan Lötvall (University of Gothenburg). In addition to research and review articles, the journal periodically publishes position papers of the society[31][32] that are meant to advance standardization efforts.

In 2014, the Executive Board of Directors of ISEV published a set of minimal information guidelines for publication of EV studies (Lötvall, et al).[33][34] These requirements, known as "MISEV" or "MISEV2014," mirrored similar initiatives in the fields of microarray (MIAME) and proteomics (MIAPE) analysis, among others. In 2017, the ISEV board announced intent to update these requirements with community involvement.[35] The "MISEV2018" requirements (Théry and Witwer, et al.) were published in JEV in 2018 with input from 382 authors.[36]

Education[edit]

Among the educational initiatives of ISEV is a massive open online course (MOOC) on the Basics of Extracellular Vesicles, launched in 2016 and available through Coursera. Coordinated by Cecilia Lässer, the MOOC is co-sponsored by the University of Gothenburg, Pohang University of Science and Technology, and the University of California, Irvine.[37]

References[edit]

  1. ^ "Better living through mitochondrial derived vesicles".
  2. ^ "Beckman Coulter Webinar Series Presents Diversity of Extracellular Vesicles and Their Cargo in Cell-to-cell Communication".
  3. ^ "ISEV 2011".
  4. ^ "ISEV 2012".
  5. ^ Ferguson, William (2013). "RNA fragments may yield rapid, accurate cancer diagnosis". Nature. doi:10.1038/nature.2013.12344.
  6. ^ "Isolation and Purification of Exosomes and Microvesicles Using the NTA Technique". 2015-04-29.
  7. ^ "ISEV 2013".
  8. ^ "ISEV 2014".
  9. ^ "NIH NCATS Newsletter February, 2015".
  10. ^ "ISEV2018".
  11. ^ "ISEV2019".
  12. ^ "ISEV2019".
  13. ^ "RNA Workshop".
  14. ^ Witwer, K. W.; Buzás, E. I.; Bemis, L. T.; Bora, A; Lässer, C; Lötvall, J; Nolte-'t Hoen, E. N.; Piper, M. G.; Sivaraman, S; Skog, J; Théry, C; Wauben, M. H.; Hochberg, F (2013). "Standardization of sample collection, isolation and analysis methods in extracellular vesicle research". Journal of Extracellular Vesicles. 2: 20360. doi:10.3402/jev.v2i0.20360. PMC 3760646. PMID 24009894.
  15. ^ Hill, A. F.; Pegtel, D. M.; Lambertz, U; Leonardi, T; O'Driscoll, L; Pluchino, S; Ter-Ovanesyan, D; Nolte-'t Hoen, E. N. (2013). "ISEV position paper: Extracellular vesicle RNA analysis and bioinformatics". Journal of Extracellular Vesicles. 2: 22859. doi:10.3402/jev.v2i0.22859. PMC 3873759. PMID 24376909.
  16. ^ "SOCRATES 2013".
  17. ^ Lener T, Gimona M, Aigner L, Börger V, Buzas E, Camussi G, Chaput N, Chatterjee D, Court FA, Del Portillo HA, O'Driscoll L, Fais S, Falcon-Perez JM, Felderhoff-Mueser U, Fraile L, Gho YS, Görgens A, Gupta RC, Hendrix A, Hermann DM, Hill AF, Hochberg F, Horn PA, de Kleijn D, Kordelas L, Kramer BW, Krämer-Albers EM, Laner-Plamberger S, Laitinen S, Leonardi T, Lorenowicz MJ, Lim SK, Lötvall J, Maguire CA, Marcilla A, Nazarenko I, Ochiya T, Patel T, Pedersen S, Pocsfalvi G, Pluchino S, Quesenberry P, Reischl IG, Rivera FJ, Sanzenbacher R, Schallmoser K, Slaper-Cortenbach I, Strunk D, Tonn T, Vader P, van Balkom BW, Wauben M, Andaloussi SE, Théry C, Rohde E, Giebel B (2015). "Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper". J Extracell Vesicles. 4: 30087. doi:10.3402/jev.v4.30087. PMC 4698466. PMID 26725829.
  18. ^ "Budapest 2013".;
  19. ^ "Proteomics and Lipidomics" (PDF).
  20. ^ "Closing Ceremony of 2015 Annual Meeting of the International Society for Extracellular Vesicles".
  21. ^ Mateescu B, Kowal EJ, van Balkom BW, Bartel S, Bhattacharyya SN, Buzás EI, Buck AH, de Candia P, Chow FW, Das S, Driedonks TA, Fernández-Messina L, Haderk F, Hill AF, Jones JC, Van Keuren-Jensen KR, Lai CP, Lässer C, Liegro ID, Lunavat TR, Lorenowicz MJ, Maas SL, Mäger I, Mittelbrunn M, Momma S, Mukherjee K, Nawaz M, Pegtel DM, Pfaffl MW, Schiffelers RM, Tahara H, Théry C, Tosar JP, Wauben MH, Witwer KW, Nolte-'T Hoen EN (2017). "Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - an ISEV position paper". J Extracell Vesicles. 6 (1): 1286095. doi:10.1080/20013078.2017.1286095. PMC 5345583. PMID 28326170.
  22. ^ Reiner AT, Witwer KW, van Balkom BW, de Beer J, Brodie C, Corteling RL, Gabrielsson S, Gimona M, Ibrahim AG, de Kleijn D, Lai CP, Lötvall J, Del Portillo HA, Reischl IG, Riazifar M, Salomon C, Tahara H, Toh WS, Wauben MH, Yang VK, Yang Y, Yeo RW, Yin H, Giebel B, Rohde E, Lim SK (2017). "Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles". Stem Cells Transl Med. 6 (8): 1730–1739. doi:10.1002/sctm.17-0055. PMC 5689784. PMID 28714557.
  23. ^ "2018 ISEV Workshop Membranes and Extracellular Vesicles".
  24. ^ "2016 ISEV Workshop".
  25. ^ "2017 ISEV WORKSHOP ON EXTRACELLULAR VESICLES AS BIOMARKERS OF DISEASE".
  26. ^ "Providence Therapeutics Meeting".
  27. ^ Keystone Symposium
  28. ^ Biologic Effects and Therapeutic Potential of Extracellular Vesicles
  29. ^ Cold Spring Harbor Asia
  30. ^ "JEV".
  31. ^ Witwer, K. W.; Buzás, E. I.; Bemis, L. T.; Bora, A; Lässer, C; Lötvall, J; Nolte-'t Hoen, E. N.; Piper, M. G.; Sivaraman, S; Skog, J; Théry, C; Wauben, M. H.; Hochberg, F (2013). "Standardization of sample collection, isolation and analysis methods in extracellular vesicle research". Journal of Extracellular Vesicles. 2: 20360. doi:10.3402/jev.v2i0.20360. PMC 3760646. PMID 24009894.
  32. ^ Hill, A. F.; Pegtel, D. M.; Lambertz, U; Leonardi, T; O'Driscoll, L; Pluchino, S; Ter-Ovanesyan, D; Nolte-'t Hoen, E. N. (2013). "ISEV position paper: Extracellular vesicle RNA analysis and bioinformatics". Journal of Extracellular Vesicles. 2: 22859. doi:10.3402/jev.v2i0.22859. PMC 3873759. PMID 24376909.
  33. ^ Lötvall, J; Hill, A. F.; Hochberg, F; Buzás, E. I.; Di Vizio, D; Gardiner, C; Gho, Y. S.; Kurochkin, I. V.; Mathivanan, S; Quesenberry, P; Sahoo, S; Tahara, H; Wauben, M. H.; Witwer, K. W.; Théry, C (2014). "Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles". Journal of Extracellular Vesicles. 3: 26913. doi:10.3402/jev.v3.26913. PMC 4275645. PMID 25536934.
  34. ^ "Enhanced Analysis of Extracellular Vesicles with Imaging Flow Cytometry".
  35. ^ PMID 29184626
  36. ^ Théry, C. (2018). "Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines". Journal of Extracellular Vesicles. 7 (1): 1535750. doi:10.1080/20013078.2018.1535750. PMC 6322352. PMID 30637094.
  37. ^ BioQuick News: "Well-Attended Two-Track Education Day Precedes Opening of International Society for Extracellular Vesicles Annual Meeting in Rotterdam"

External links[edit]