I-195 begins at the eastern end of the I-95 and SR 112 interchange, heading east with interchanges with Miami Avenue and U.S. Route 1 (US 1) before heading onto the Julia Tuttle Causeway, where the interstate crosses Biscayne Bay. At the eastern end of the causeway in Miami Beach, it has an interchange with SR 907 before terminating at the intersection of SR 907A and Arthur Goodfrey Road, about a mile west of SR A1A.
On December 23, 1961, three signed roads along the route of SR 112 were opened: the 36th Street Tollway (now the Airport Expressway), I-195, and I-195 Spur, along with a stretch of I-95 in Miami. I-195 Spur was the surface portion of the west–east state road along Arthur Godfrey Road in Miami Beach, connecting I-195 and SR A1A east of the causeway. The I-195 Spur signs disappeared from the road shortly after the designation was decommissioned by the newly formed United States Department of Transportation in the late 1960s.
Famously, in early 1975, the rhythm of their car on this road was the inspiration for the Bee Gees' song Jive Talkin'.