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Interstate 270 is the designation for four Interstate Highways in the United States, all of which are related to Interstate 70:
- Interstate 270 (Colorado), a northeastern bypass of downtown Denver
- Interstate 270 (Illinois–Missouri), a partial beltway around St. Louis
- Interstate 270 (Maryland), a connector to the Washington, D.C. metropolitan area
- Interstate 270 (Ohio), a beltway around Columbus, Ohio
| disambiguation page lists articles about roads and streets with the same name.
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