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Interstate 680 may refer to:
- Interstate 680 (California), a connecting freeway between I-80 and I-280 in the San Francisco Bay Area, California
- Interstate 680 (Iowa–Nebraska), a bypass in Omaha, Nebraska
- Interstate 680 (Ohio), a loop through Youngstown, Ohio
- Interstate 676 in Pennsylvania and New Jersey, designated as Interstate 680 back when I-76 was I-80S
| disambiguation page lists articles about roads and streets with the same name.
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