I-759 begins at Exit 182 of I-59 in Attalla. From this point the route travels in an easterly direction across a marshy area prior to reaching its first exit at Black Creek Parkway, a diamond interchange. From the Black Creek exit, I-759 continues in its easterly direction and crosses the Coosa River along a causeway and short bridge prior to reaching US 411. At the US 411 interchange, the I-759 designation ends, but the route continues as SR 759 in spanning the Coosa River.
Currently, there are plans to extend I-759 east to US 278 on the east side of Gadsden, as well as west towards Attalla and linking it to SR 77. This would mean that SR 759 would be completely Removed.