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Interstate 76 may refer to:
- Interstate 76 (Ohio–New Jersey), an Interstate Highway in the United States, running through Ohio, Pennsylvania, and New Jersey
- Interstate 76 in Ohio and Ohio Turnpike spans the Ohio segment
- Pennsylvania Turnpike, which includes the western section of Interstate 76 in Pennsylvania
- Schuylkill Expressway, the easternmost segment of Interstate 76 in Pennsylvania
- A former designation of the Penn-Lincoln Parkway in the Pittsburgh metropolitan area (1964 to the 1970s)
- Interstate 76 (Colorado–Nebraska), an Interstate Highway in the United States, running through Colorado and Nebraska
- Interstate '76, a vehicular combat video game for Windows
- Interstate 76 in Pennsylvania disambiguation page
| disambiguation page lists articles about roads and streets with the same name.
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