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Intragenomic conflict refers to the evolutionary phenomenon where genes have phenotypic effects that promote their own transmission in detriment of the transmission of other genes that reside in the same genome. The selfish gene theory postulates that natural selection will increase the frequency of those genes whose phenotypic effects cause their transmission to new organisms, and most genes achieve this by cooperating with other genes in the same genome to build an organism capable of reproducing and/or helping kin to reproduce. The assumption of the prevalence of intragenomic cooperation underlies the organism-centered concept of inclusive fitness. However, conflict among genes in the same genome may arise both in events related to reproduction (a gene may "cheat" and increase its own presence in gametes or offspring above the expected according to fair Mendelian segregation and fair gametogenesis) and altruism (genes in the same genome may disagree on how to value other organisms in the context of helping kin because coefficients of relatedness diverge between genes in the same genome).
- 1 Nuclear genes
- 2 Cytoplasmic genes
- 3 Evolution of sex
- 4 See also
- 5 References
- 6 Further reading
Autosomic genes usually have the same mode of transmission in sexually reproducing species due to the fairness of Mendelian segregation, but conflicts among alleles of autosomic genes may arise when an allele cheats during gametogenesis (segregation distortion) or eliminates embryos that don't contain it (lethal maternal effects). An allele may also directly convert its rival allele into a copy of itself (homing endonucleases). Finally, mobile genetic elements completely bypass Mendelian segregation, being able to insert new copies of themselves into new positions in the genome (transposons).
In principle, the two parental alleles have equal probabilities of being present in the mature gamete. However, there are several mechanisms that lead to an unequal transmission of parental alleles from parents to offspring. One example is a gene, called a segregation distorter, that "cheats" during meiosis or gametogenesis and thus is present in more than half of the functional gametes. The most studied examples are sd in Drosophila melanogaster (fruit fly), t haplotype in Mus musculus (mouse) and sk in Neurospora spp. (fungus). Possible examples have also been reported in humans. Segregation distorters that are present in sexual chromosomes (as is the case with the X chromosome in several Drosophila species) are denominated sex-ratio distorters, as they induce a sex-ratio bias in the offspring of the carrier individual.
Killer and target
The most simple model of meiotic drive involves two tightly linked loci: a Killer locus and a Target locus. The segregation distorter set is composed by the allele Killer (in the Killer locus) and the allele Resistant (in the Target locus), while its rival set is composed by the alleles Non-killer and Non-resistant. So, the segregation distorter set produces a toxin to which it is itself resistant, while its rival is not. Thus, it kills those gametes containing the rival set and increases in frequency. The tight linkage between these loci is crucial, so these genes usually lie on low-recombination regions of the genome.
True meiotic drive
Other systems do not involve gamete destruction, but rather use the asymmetry of meiosis in females: the driving allele ends up in the oocyte instead of in the polar bodies with a probability greater than one half. This is termed true meiotic drive, as it does not rely on a post-meiotic mechanism. The best-studied examples include the neocentromeres (knobs) of maize, as well as several chromosomal rearrangements in mammals. The general molecular evolution of centromeres is likely to involve such mechanisms.
Lethal maternal effects
The Medea gene causes the death of progeny from a heterozygous mother that do not inherit it. It occurs in the flour beetle (Tribolium castaneum). Maternal-effect selfish genes have been successfully synthesized in the lab.
Transposons are autonomous replicating genes that encode the ability to move to new positions in the genome and therefore accumulate in the genomes. They replicate themselves in spite of being detrimental to the rest of the genome. They are often called 'jumping genes' or parasitic DNA and were discovered by Barbara McClintock in 1944.
Homing endonuclease genes
Homing endonuclease genes (HEG) convert their rival allele into a copy of themselves, and are thus inherited by nearly all meiotic daughter cells of a heterozygote cell. They achieve this by encoding an endonuclease which breaks the rival allele. This break is repaired by using the sequence of the HEG as template.
HEGs encode sequence-specific endonucleases. The recognition sequence (RS) is 15–30 bp long and usually occurs once in the genome. HEGs are located in the middle of their own recognition sequences. Most HEGs are encoded by self-splicing introns (group I & II) and inteins. Inteins are internal protein fragments produced from protein splicing and usually contain endonuclease and splicing activities. The allele without the HEGs are cleaved by the homing endonuclease and the double-strand break are repaired by homologous recombination (gene conversion) using the allele containing HEGs as template. Both chromosomes will contain the HEGs after repair.
B-chromosomes are nonessential chromosomes; not homologous with any member of the normal (A) chromosome set; morphologically and structurally different from the A's; and they are transmitted at higher-than-expected frequencies, leading to their accumulation in progeny. In some cases, there is strong evidence to support the contention that they are simply selfish and that they exist as parasitic chromosomes. They are found in all major taxonomic groupings of both plants and animals.
Since nuclear and cytoplasmic genes usually have different modes of transmission, intragenomic conflicts between them may arise. Mitochondrias and chloroplasts are two examples of sets of cytoplasmic genes that commonly have exclusive maternal inheritance, similar to endosymbiont parasites in arthropods, like Wolbachia.
Males as dead-ends to cytoplasmic genes
Anisogamy generally produces zygotes that inherit cytoplasmic elements exclusively from the female gamete. Thus, males represent dead-ends to these genes. Because of this fact, cytoplasmic genes have evolved a number of mechanisms to increase the production of female descendants and eliminate offspring not containing them.
Male organisms are converted into females by cytoplasmic inherited protists (Microsporidia) or bacteria (Wolbachia), regardless of nuclear sex-determining factors. This occurs in amphipod and isopod Crustacea and Lepidoptera.
Male embryos (in the case of cytoplasmic inherited bacteria) or male larvae (in the case of Microsporidia) are killed. In the case of embryo death, this diverts investment from males to females who can transmit these cytoplasmic elements (for instance, in ladybird beetles, infected female hosts eat their dead male brothers, which is positive from the viewpoint of the bacterium). In the case of microsporidia-induced larval death, the agent is transmitted out of the male lineage (through which it cannot be transmitted) into the environment, where it may be taken up again infectiously by other individuals. Male-killing occurs in many insects. In the case of male embryo death, a variety of bacteria have been implicated, including Wolbachia.
In some cases anther tissue (male gametophyte) is killed by mitochondria in monoecious angiosperms, increasing energy and material spent in developing female gametophytes. This leads to a shift from monoecy to gynodioecy, where part of the plants in the population are male-sterile.
In certain haplodiploid Hymenoptera and mites, in which males are produced asexually, Wolbachia and Cardinium can induce duplication of the chromosomes and thus convert the organisms into females. The cytoplasmic bacterium forces haploid cells to go through incomplete mitosis to produce diploid cells which therefore will be female. This produces an entirely female population. Interestingly, if antibiotics are administered to populations which have become asexual in this way, they revert to sexuality instantly, as the cytoplasmic bacteria forcing this behaviour upon them are removed.
Evolution of sex
Conflict between chromosomes has been proposed as an element in the evolution of sex.
- Gardner, Andy; Úbeda, Francisco (2017-11-06). "The meaning of intragenomic conflict". Nature Ecology & Evolution. doi:10.1038/s41559-017-0354-9. ISSN 2397-334X.
- Austin., Burt, (2006). Genes in conflict : the biology of selfish genetic elements. Trivers, Robert. Cambridge, MA: Belknap Press of Harvard University Press. ISBN 9780674027220. OCLC 647823687.
- Spencer, Hamish G (2003). Intragenomic conflict. eLS. John Wiley & Sons, Ltd. doi:10.1038/npg.els.0001714. ISBN 9780470015902.
- Hurst, Laurence D.; Atlan, Anne; Bengtsson, Bengt O. (1996-09-01). "Genetic Conflicts". The Quarterly Review of Biology. 71 (3): 317–364. doi:10.1086/419442. ISSN 0033-5770.
- 1941-, Dawkins, Richard, (1976). The selfish gene. New York: Oxford University Press. ISBN 019857519X. OCLC 2681149.
- Ågren, J. Arvid (2016-12-01). "Selfish genetic elements and the gene's-eye view of evolution". Current Zoology. 62 (6): 659–665. doi:10.1093/cz/zow102. ISSN 1674-5507.
- Werren, John H. (2011-06-28). "Selfish genetic elements, genetic conflict, and evolutionary innovation". Proceedings of the National Academy of Sciences. 108 (Supplement 2): 10863–10870. doi:10.1073/pnas.1102343108. ISSN 0027-8424. PMID 21690392.
- Rice, William R. (2013-11-23). "Nothing in Genetics Makes Sense Except in Light of Genomic Conflict". Annual Review of Ecology, Evolution, and Systematics. 44 (1): 217–237. doi:10.1146/annurev-ecolsys-110411-160242. ISSN 1543-592X.
- Larracuente, Amanda M.; Presgraves, Daven C. (1 September 2012). "The Selfish Segregation Distorter Gene Complex of Drosophila melanogaster". Genetics. 192 (1): 33–53. doi:10.1534/genetics.112.141390. PMID 22964836 – via www.genetics.org.
- Yang, Liu; Liangliang Zhang; Shuhua Xu; Landian Hu; Laurence D. Hurst; Xiangyin Kong (July 2013). "Identification of Two Maternal Transmission Ratio Distortion Loci in Pedigrees of the Framingham Heart Study". Scientific Reports. 3. doi:10.1038/srep02147. PMC . PMID 23828458. Retrieved 10 July 2013.
- ""Sex Ratio" Meiotic Drive in Drosophila testacea" (PDF).
- Sturtevant AH, Dobzhansky T (Jul 1936). "Geographical Distribution and Cytology of "Sex Ratio" in Drosophila Pseudoobscura and Related Species" (PDF). Genetics. 21: 473–90. PMC . PMID 17246805.
- R. W. Beeman; K. S. Friesen; R. E. Denell (1992). "Maternal-effect selfish genes in flour beetles" (PDF). Science. 256 (5053): 89–92. doi:10.1126/science.1566060. PMID 1566060.
- Chun-Hong Chen; Haixia Huang; Catherine M. Ward; Jessica T. Su; Lorian V. Schaeffer; Ming Guo; Bruce A. Hay (2007). "A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila". Science. 316 (5824): 597–600. doi:10.1126/science.1138595. PMID 17395794.
- Steven P. Sinkins; Fred Gould (2006). "Gene drive systems for insect disease vectors" (PDF). Nature Reviews Genetics. 7 (6): 427–435. doi:10.1038/nrg1870. PMID 16682981.
- Austin Burt; Vassiliki Koufopanou (2004). "Homing endonuclease genes: the rise and fall and rise again of a selfish element". Current Opinion in Genetics & Development. 14 (6): 609–615. doi:10.1016/j.gde.2004.09.010. PMID 15531154.
- Östergren, G. (1947). "Heterochromatic B-Chromosomes in Anthoxanthum". Hereditas. 33 (1–2): 261–296. doi:10.1111/j.1601-5223.1947.tb02804.x.
- Murlas Cosmides, Leda; Tooby, John. "Cytoplasmic inheritance and intragenomic conflict". Journal of Theoretical Biology. 89 (1): 83–129. doi:10.1016/0022-5193(81)90181-8.
- Duron, Olivier; Bouchon, Didier; Boutin, Sébastien; Bellamy, Lawrence; Zhou, Liqin; Engelstädter, Jan; Hurst, Gregory D. (2008-06-24). "The diversity of reproductive parasites among arthropods: Wolbachiado not walk alone". BMC Biology. 6: 27. doi:10.1186/1741-7007-6-27. ISSN 1741-7007.
- Jan Engelstädter; Gregory D. D. Hurst (2009). "The ecology and evolution of microbes that manipulate host reproduction". Annual Review of Ecology, Evolution, and Systematics. 140: 127–149. doi:10.1146/annurev.ecolsys.110308.120206.
- Julian D. O'Dea (2006). "Did conflict between chromosomes drive the evolution of sex?". Calodema. Sydney: Trevor J. Hawkeswood. 8: 33–34. See also the author's blog post.
- Burt, A. & R. L. Trivers (2006). Genes in Conflict: the Biology of Selfish Genetic Elements. Harvard: Belknap Press. ISBN 0-674-01713-7.
- Cosmides, L. M. & J. Tooby (1981). "Cytoplasmic inheritance and intragenomic conflict". Journal of Theoretical Biology. 89 (1): 83–129. CiteSeerX . doi:10.1016/0022-5193(81)90181-8. PMID 7278311.
- Dawkins, R. (1976). The Selfish Gene. Oxford: Oxford University Press. ISBN 0-19-217773-7.
- Eberhard, W. G. (1980). "Evolutionary consequences of intracellular organelle competition" (PDF). The Quarterly Review of Biology. 55 (3): 231–249. doi:10.1086/411855. JSTOR 2824738. PMID 7208806.
- Haig, D. (1997). "The social gene". In J. R. Krebs, & N. B. Davies. Behavioural Ecology: an Evolutionary Approach (4th ed.). London: Blackwell Publishers. pp. 284–304. ISBN 978-0-86542-731-0.
- Hurst, L. D., A. Atlan & B. O. Bengtsson (1996). "Genetic conflicts". The Quarterly Review of Biology. 71 (3): 317–364. doi:10.1086/419442. JSTOR 3035920. PMID 8828237.
- Hurst, G. D. D.; J. H. Werren (2001). "The role of selfish genetic elements in eukaryotic evolution". Nature Reviews Genetics. 2 (8): 597–606. CiteSeerX . doi:10.1038/35084545. PMID 11483984.
- Jones, R. N. (1991). "B-chromosome drive". The American Naturalist. 137 (3): 430–442. doi:10.1086/285175. JSTOR 2462577.