Intramyocellular lipids

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Intramyocellular lipids (or IMCL) are fats stored in droplets in muscle cells. They provide an important energy source for working muscle. During exercise, a large amount of circulating free fatty acids are directed into muscle cells for energy; during rest, incoming fatty acids are instead stored in the muscle cell as triglycerides for later burning.[1] However, an increase in muscle insulin resistance, caused by obesity, diabetes mellitus type 2, and metabolic syndrome, will result in an excess accumulation of intramyocellular lipids.[2][3]

Other expert opinions and researchers argue the exact opposite: that accumulation of intramyocellular lipids would, in fact, be the cause of the insulin resistance that leads to type II diabetes.[4][5][6][7]

See also[edit]

Insulin glargine


  1. ^ Schrauwen-Hinderling VB, van Loon LJ, Koopman R, Nicolay K, Saris WH, Kooi ME (December 1, 2003). "Intramyocellular lipid content is increased after exercise in nonexercising human skeletal muscle". Journal of Applied Physiology. 95 (6): 2328–2332. doi:10.1152/japplphysiol.00304.2003. PMID 12923116.
  2. ^ Guo ZK (2007). "Intramyocellular lipid kinetics and insulin resistance". Lipids Health Dis. 6: 18. doi:10.1186/1476-511X-6-18. PMC 1971250. PMID 17650308.
  3. ^ Greco AV, Mingrone G, Giancaterini A, Manco M, Morroni M, Cinti S, Granzotto M, Vettor R, Camastra S, Ferrannini E (2002). "Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion". Diabetes. 51 (1): 144–51. doi:10.2337/diabetes.51.1.144. PMID 11756334.
  4. ^ Barnard, Neal (2007). Dr. NYC, NY: Rodale. p. 23. ISBN 9781594868108.
  5. ^ Barnard, B. Dr. Neal Barnard's Program for Reversing Diabetes: The Scientifically Proven System for Reversing Diabetes without Drugs
  6. ^ Esselstyn, C.B. Prevent and Reverse Heart Disease: The Revolutionary, Scientifically Proven, Nutrition-Based Cure
  7. ^ Campbell, T.C. The China Study: The Most Comprehensive Study of Nutrition Ever Conducted and the Startling Implications for Diet, Weight Loss and Long-Term Health

External links[edit]