Intramyocellular lipids are fats stored in droplets in muscle cells. They provide an important energy source for working muscle. During exercise, a large amount of circulating free fatty acids are directed into muscle cells for energy; during rest, incoming fatty acids are instead stored in the muscle cell as triglycerides for later burning. However, an increase in muscle insulin resistance, caused by obesity, diabetes mellitus type 2, and metabolic syndrome, will result in an excess accumulation of intramyocellular lipids.
Other expert opinions and researchers argue the exact opposite: that accumulation of intramyocellular lipids would, in fact, be the cause of the insulin resistance that leads to type II diabetes.
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- Guo ZK (2007). "Intramyocellular lipid kinetics and insulin resistance". Lipids Health Dis. 6: 18. doi:10.1186/1476-511X-6-18. PMC 1971250. PMID 17650308.
- Greco AV, Mingrone G, Giancaterini A, Manco M, Morroni M, Cinti S, Granzotto M, Vettor R, Camastra S, Ferrannini E (2002). "Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion". Diabetes. 51 (1): 144–51. doi:10.2337/diabetes.51.1.144. PMID 11756334.
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