Intraocular pressure (IOP) is the fluid pressure inside the eye. Tonometry is the method eye care professionals use to determine this. IOP is an important aspect in the evaluation of patients at risk of glaucoma. Most tonometers are calibrated to measure pressure in millimeters of mercury (mmHg).
Intraocular pressure is mainly determined by the coupling of the production of aqueous humor and the drainage of aqueous humor mainly through the trabecular meshwork located in the anterior chamber angle. The reason for this is because the vitreous humour in the posterior segment has a relatively fixed volume and thus does not affect intraocular pressure regulation.
An important quantitative relationship is provided below:
- Po is the IOP in millimeters of mercury (mmHg)
- F the rate of aqueous humour formation in microliters per minute (μL/min)
- U the resorption of aqueous humour through the uveoscleral route (in μL/min)
- C is the facility of outflow in microliters per minute per millimeter of mercury (μL/min/mmHg)
- Pv the episcleral venous pressure in millimeters of mercury (mmHg).
The above factors are those that drive IOP.
Measured values of intraocular pressure are influenced by corneal thickness and rigidity. As a result, some forms of refractive surgery (such as photorefractive keratectomy) can cause traditional intraocular pressure measurements to appear normal when in fact the pressure may be abnormally high. A newer transpalpebral and transscleral tonometry method is not influenced by corneal biomechanics and does not need to be adjusted for corneal irregularities as measurement is done over upper eyelid and sclera.
Current consensus among ophthalmologists and optometrists define normal intraocular pressure as that between 10 mmHg and 20 mmHg. The average value of intraocular pressure is 15.5 mmHg with fluctuations of about 2.75 mmHg.
Ocular hypotension, Hypotony, or ocular hypotony, is typically defined as intraocular pressure equal to or less than 5 mmHg. Such low intraocular pressure could indicate fluid leakage and deflation of the eyeball.
Intraocular pressure varies throughout the night and day. The diurnal variation for normal eyes is between 3 and 6 mmHg and the variation may increase in glaucomatous eyes. During the night, intraocular pressure may not decrease despite the slower production of aqueous humour. In the general population, IOP ranges between 10 and 21 mm Hg with a mean of about 15 or 16 mm Hg (plus or minus 3.5 mm Hg during a 24-hour cycle). In glaucoma patients, their 24-hour IOP profiles may be different from healthy individuals.
Fitness and exercise
Playing some musical wind instruments has been linked to increases in intraocular pressure. One 2011 study focused on brass and woodwind instruments observed "temporary and sometimes dramatic elevations and fluctuations in IOP". Another study found that the magnitude of increase in intraocular pressure correlates with the intraoral resistance associated with the instrument, and linked intermittent elevation of intraocular pressure from playing high-resistance wind instruments to incidence of visual field loss. The range of intraoral pressure involved in various classes of ethnic wind instruments, such as Native American flutes, has been shown to be generally lower than Western classical wind instruments.
Intraocular pressure also varies with a number of other factors such as heart rate, respiration, fluid intake, systemic medication and topical drugs. Alcohol and marijuana consumption leads to a transient decrease in intraocular pressure and caffeine may increase intraocular pressure.
Taken orally, glycerol (often mixed with fruit juice to reduce its sweet taste) can cause a rapid, temporary decrease in intraocular pressure. This can be a useful initial emergency treatment of severely elevated pressure.
The depolarising muscle relaxant succinylcholine, which is used in anaesthesia, transiently increases IOP by around 10mmHg for a few minutes. This is significant for example if the patient requires anaesthesia for a trauma and has sustained an eye (globe) perforation. The mechanism is not clear but it is thought to involve contraction of tonic myofibrils and transient dilation of choroidal blood vessels. Ketamine also increases IOP.
Ocular hypertension is the most important risk factor for glaucoma.
Intraocular pressure has been measured as a secondary outcome in a systematic review comparing the effect of neuroprotective agents in slowing the progression of open angle glaucoma.
Intraocular pressure may become elevated due to anatomical problems, inflammation of the eye, genetic factors, or as a side-effect from medication. Intraocular pressure laws follow fundamentally from physics. Any kinds of intraocular surgery should be done by considering the intraocular pressure fluctuation. Sudden increase of intraocular pressure can lead to intraocular micro barotrauma and cause ischemic effects and mechanical stress to retinal nerve fiber layer. Sudden intraocular pressure drop can lead to intraocular decompression that generates micro bubbles that potentially cause multiple micro emboli and leading to hypoxia, ischemia and retinal micro structure damage.
- Farandos NM, Yetisen AK, Monteiro MJ, Lowe CR, Yun SH (April 2015). "Contact lens sensors in ocular diagnostics". Adv Healthc Mater. 4 (6): 792–810. doi:10.1002/adhm.201400504. PMID 25400274.
- Aptel F, Weinreb RN, Chiquet C, Mansouri K (November 2016). "24-h monitoring devices and nyctohemeral rhythms of intraocular pressure". Prog Retin Eye Res. 55: 108–148. doi:10.1016/j.preteyeres.2016.07.002. PMID 27477112.
- Grieshaber MC, Schoetzau A, Zawinka C, Flammer J, Orgul S (June 2007). "Effect of central corneal thickness on dynamic contour tonometry and Goldmann applanation tonometry in primary open-angle glaucoma". Arch. Ophthalmol. 125 (6): 740–4. doi:10.1001/archopht.125.6.740. PMID 17562982.
- Tanaka GH (April 1998). "Corneal pachymetry: a prerequisite for applanation tonometry?". Arch. Ophthalmol. 116 (4): 544–5. PMID 9565063.
- Cacho I, Sanchez-Naves J, Batres L, Pintor J, Carracedo G (2015). "Comparison of Intraocular Pressure before and after Laser In Situ Keratomileusis Refractive Surgery Measured with Perkins Tonometry, Noncontact Tonometry, and Transpalpebral Tonometry". J Ophthalmol. 2015: 683895. doi:10.1155/2015/683895. PMC 4475733. PMID 26167293.
- webMD - Tonometry
- Glaucoma Overview from eMedicine
- Janunts E. "Optical remote sensing of intraocular pressure by an implantable nanostructured array". Medizinische Fakultät der Universität des Saarlandes. Archived from the original on 2012-04-25.
- Vieira GM, Oliveira HB, de Andrade DT, Bottaro M, Ritch R (September 2006). "Intraocular pressure variation during weight lifting". Arch. Ophthalmol. 124 (9): 1251–4. doi:10.1001/archopht.124.9.1251. PMID 16966619.
- Ocular Hypertension, American Optometric Association. Accessed 2015-11-3.
- "Ocular Hypotony: Background, Pathophysiology, Epidemiology". Medscape Reference. 2014-02-05. Retrieved 2015-11-04.
- Henderer JD, Budenz DL, Flynn HW, Schiffman JC, Feuer WJ, Murray TG (February 1999). "Elevated intraocular pressure and hypotony following silicone oil retinal tamponade for complex retinal detachment: incidence and risk factors". Arch. Ophthalmol. 117 (2): 189–95. doi:10.1001/archopht.117.2.189. PMID 10037563.
- Liu JH, Weinreb RN (May 2011). "Monitoring intraocular pressure for 24 h". Br J Ophthalmol. 95 (5): 599–600. doi:10.1136/bjo.2010.199737. PMID 21330554.
- Brubaker RF (1991). "Flow of aqueous humor in humans". Invest Ophthalmol Vis Sci. 32 (13): 3145–3166. PMID 1748546.
- Hashemi H, Kashi AH, Fotouhi A, Mohammad K (June 2005). "Distribution of intraocular pressure in healthy Iranian individuals: the Tehran Eye Study". Br J Ophthalmol. 89 (6): 652–7. doi:10.1136/bjo.2004.058057. PMC 1772663. PMID 15923494.
- Pooranee (2015-10-09). "Do you know about Intra Ocular Pressure?". Health Education Bureau, Information and Communication Technology Agency, Sri Lanka. Retrieved 2015-11-04.
- Liu JH, Zhang X, Kripke DF, Weinreb RN (April 2003). "Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changes". Invest. Ophthalmol. Vis. Sci. 44 (4): 1586–90. doi:10.1167/iovs.02-0666. ISSN 1552-5783. PMID 12657596.
- Studies have also been conducted on both healthy and sedentary individuals to determine if intraocular pressure could be reduced with other types of exercise. Some forms of exertion have been found to result in a decrease in intraocular pressure. Exercises studied included; walking, jogging, and running. Acute Dynamic Exercise Reduces Intraocular Pressure, Departments of Ophthalmology, Physiology, Faculty of Medicine, Atatürk University, Erzurum- Turkey. July 1999.
- Qureshi IA. Effects of mild, moderate and severe exercise on intraocular pressure of sedentary subjects. Rawalpindi Medical College, Rawalpindi, Pakistan
- Schmidtmann G, Jahnke S, Seidel EJ, Sickenberger W, Grein HJ (June 2011). "Intraocular pressure fluctuations in professional brass and woodwind musicians during common playing conditions". Graefes Arch. Clin. Exp. Ophthalmol. 249 (6): 895–901. doi:10.1007/s00417-010-1600-x. PMID 21234587.
- Schuman JS, Massicotte EC, Connolly S, Hertzmark E, Mukherji B, Kunen MZ (January 2000). "Increased intraocular pressure and visual field defects in high resistance wind instrument players". Ophthalmology. 107 (1): 127–33. doi:10.1016/s0161-6420(99)00015-9. PMID 10647731.
- Clinton F. Goss (August 2013). "Intraoral Pressure in Ethnic Wind Instruments" (PDF). Flutopedia. arXiv:1308.5214. Bibcode:2013arXiv1308.5214G. Retrieved 22 Aug 2013.
- Intraocular pressure measure on normal eyes by Pardianto G et al., in Mimbar Ilmiah Oftalmologi Indonesia.2005;2:78-9.
- Drance SM (October 1964). "Effect of Oral Glycerol on Intraocular Pressure in Normal and Glaucomatous Eyes". Arch. Ophthalmol. 72: 491–3. doi:10.1001/archopht.1964.00970020491009. PMID 14184494.
- Brunton L, Chabner BA, Knollman B (2011). "19. General Anesthetics and Therapeutic Gases". Goodman & Gilman's: The Pharmacological Basis of Therapeutics (12th ed.). New York, USA: The McGraw-Hill Companies, Inc. p. 539. ISBN 978-0-07-162442-8.
- Sena DF, Lindsley K (January 2017). "Neuroprotection for treatment of glaucoma in adults". Cochrane Database Syst Rev. 1: CD006539. doi:10.1002/14651858.CD006539.pub4. PMC 5370094. PMID 28122126.
- Pardianto G (March 2015). "Recent awareness and consideration of intraocular pressure fluctuation during eye surgery". J Cataract Refract Surg. 41 (3): 695. doi:10.1016/j.jcrs.2015.01.009. PMID 25804599.