The distribution of I. bütschlii is worldwide. Most likely to be the original host, pigs are often targeted with I. bütschlii. I. bütschlii is identified as a non-pathogenic parasite. Often, this parasite is mistaken as a pathogenic parasite because non-pathogenic and pathogenic parasites have the same characteristics. In terms of illnesses, humans have a low prevalence of I. bütschlii (4-8%). I. butschlii is an indicator of oral-fecal contamination and humans may experience diarrhea.
The trophozoites are 9–14 micrometres in diameter. Trophozoites are one of the two forms of I.bütschlii. This form has a pseudopodia for locomotion. The pseudopodia is short and blunt. It moves in a slow manner. The trophozoite has a single nucleus, prominent for nuclear endosome and many cytoplasmic vacuoles. The ectoplasm and the granular endoplasm are often hard to distinguish. The nucleus is fairly large and vesicular, containing a large endosome, surrounding by light staining granules about midway between it and the nuclear membrane. Achromatic strands stretch between the endosome and nuclear membrane without any peripheral granules. Food vacuoles are commonly filled with bacteria and yeast. Trophozoites are often identified by a stool smear, found in loose stools.
The cysts are 8–10 micrometres in diameter, with a thick wall and a large glycogen vacuole that stains darkly with iodine. Usually harmless, it may cause amebiasis in immunologically compromised individuals.  As the second form of I. butschlii, cysts have an oval shaped- single nucleus with a prominent nuclear endosome. This form is also large, single, glycogen-filled vacuole called iodinophilous vacuole (glycogen stains with iodine). Cysts are the infective stage of I. bütschlii. Unlike trophozoites, cysts are often found in formed stools.
trophozoite in cecum & colon-->cyst in feces- ingested-->trophozoite in cecum & colon
In a research study, amebas were seen in stool samples of a patient and identified as I. bütschlii. The patient was treated with dehydroemetine and chloroquine. After treatment they noticed the patient’s complement fixation titer decreased to 1:2 in a serum sample, obtained two months later.
- "Definition: Iodamoeba from Online Medical Dictionary".
- "Iodamoeba". Retrieved 2009-01-17.
- Roberts/Janovy, Larry/John (2008). Foundations of Parasitology 8th edition. McGraw-Hill Science/Engineering/Math. pp. 115–116. ISBN 978-0-07-302827-9.
- Sullivan, John (2009). A Color Atlas of Parasitology. San Francisco, CA: University of San Francisco. p. 36. ISBN 978-0-9665807-7-8.
- "OSPHL Image Library: Iodamoeba beutschli". Retrieved 2009-01-17.
- "Non-pathogenic amoeba". Retrieved 2009-01-17.
- VISVESVARA and STEHR-GREEN, GOVINDA and JEANETTE (July–August 1990). "Epidemiology of Free-Living Ameba Infections". Journal of Eukaryotic Microbiology. 47 (4): 7. doi:10.1111/j.1550-7408.1990.tb01142.x.