Iofendylate

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Iophendylate
Iofendylate.png
Clinical data
Trade names Myodil, Pantopaque
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
ECHA InfoCard 100.002.534
Chemical and physical data
Formula C19H29IO2
Molar mass 416.33683
3D model (JSmol)
 NYesY (what is this?)  (verify)

Iofendylate is a molecule that was used as a radiocontrast agent, typically for performing myelography studies. It was marketed under the trade names Pantopaque (in North America) and Myodil (rest of the world).

Iofendylate is an iodobenzene (an iodinated oil-based substance) and as such it was recommended that the physician remove it from the patient at the end of the myelography study, which was a difficult and painful part of the procedure. Moreover, because complete removal could not always be achieved (or even attempted by some physicians), iofendylate's persistence in the body might sometimes lead to arachnoiditis, a potentially painful and debilitating lifelong disorder of the spine.[1][2] As a result, the substance, which was used extensively for over three decades, became the subject of multiple lawsuits filed around the world.[3]

Iofendylate's use ceased when water-soluble agents suitable for spinal enhancement (such as metrizamide) became available in the late 1970s. With those substances it was no longer necessary to remove the contrast agent as it would eventually be absorbed into the body. Also, with the advent of MRI, myelography studies are nowadays much less-frequently performed.

References[edit]

  1. ^ Dunlevy, Sue (10 December 2016). "Australians crippled and in chronic pain from dye used in toxic X-rays". The Daily Telegraph. Retrieved 27 October 2017. 
  2. ^ William P. Dillon; Christopher F. Dowd (2014). "Chapter 53 – Neurologic Complications of Imaging Procedures". Aminoff's Neurology and General Medicine (5th ed.). Elsevier Academic Press. pp. 1089–1105. ISBN 978-0-12-407710-2. 
  3. ^ Myodil litigation

External links[edit]