Ionomycin

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ionomycin
Ionomycin (free acid).svg
Names
IUPAC name
(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-Dihydroxy-22-{(2S,2′R,5S,5′S)-5′-[(1R)-1-hydroxyethyl]-2,5′-dimethyloctahydro-2,2′-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoic acid
Identifiers
56092-81-0 YesY
3D model (Jmol) Interactive image
ChEMBL ChEMBL501617 N
ChEMBL1222121 N
ChemSpider 5288579 N
ECHA InfoCard 100.121.228
PubChem 6912226
Properties
C41H72O9
Molar mass 709.0050
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus.[1] It is used in research to raise the intracellular level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. It is also used to stimulate the intracellular production of the following cytokines; interferon, perforin, IL-2, and IL-4 - usually in conjunction with PMA. These cytokines are important in the inflammatory response.

Commercially, Ionomycin can be obtained as a free acid, or as a Ca2+ salt.

References[edit]

  1. ^ See Ionomycin Calcium salt from Fermentek, manufacturer's product page for ionomycin