According to an aviation website, the airline's historic links go back to 1958 to the airline Air Taxi Co., which became Pars Air in the 1970s and later Iran Aseman Airlines. Aseman was the first aviation company in the Middle East to provide Air Ambulance services.
Iran Aseman Airlines is the sole representative in the Middle East of the Dassault-Breguet Mystere-Falcon company, and it is the only independent company in the Islamic Republic of Iran that operates two Jet Falcon 20 aircraft for air ambulance services.
On 4 October 1990, an Iran Aseman Fokker F27 Friendship (registered EP-ANA) overran the runway upon landing at Ramsar Airport, Iran and came to rest at a concrete wall 100 metres behind the runway. There were no fatalities amongst the 46 passengers and 4 crew members on board, and the aircraft could be repaired.
On 18 July 2000, Iran Aseman Airlines Flight 775, a Fokker F28 Fellowship (registered EP-PAU) en route from Tehran to Ahwaz, was damaged beyond repair when the pilot missed the runway upon a low-visibility landing attempt at Ahwaz Airport and instead touched down next to it. A successful go-around was executed, and there were no injuries amongst the 84 passengers and 4 crew members on board.
On 26 August 2010, a Fokker 100 (registered EP-ASL) operating Iran Aseman Airlines Flight 773 from Tehran to Tabriz overran the runway upon landing at Tabriz International Airport and was substantially damaged when it plunged into a canal. Two out of the 103 passengers on board were injured, while the 7 crew members were not hurt.
 On 10 May 2014, a Fokker 100 (registered EP-ASZ), was damaged in a landing accident at Zahedan Airport (ZAH), Iran. The airplane operated flight 853 from Mashhad Airport (MHD). According to local media the left hand main undercarriage failed to extend or lock prior to landing. A forced landing was carried out on runway 35. The airplane swerved to the left and came to rest 1450 meters (4760 feet) past the runway 35 threshold and 23 meters (75 feet) to the left of the centreline.