Irazepine

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Irazepine
Irazepine.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C18H13ClFN3OS
Molar mass 373.83 g/mol
3D model (JSmol)
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Irazepine (Ro 7-1986/1) is a benzodiazepine derivative containing isothiocyanate functional group.[1] It is a non-competitive benzodiazepine binding site antagonist.[2] Irazepine and other alkylating benzodiazepine, kenazepine, bind to brain benzodiazepine receptors in a non-competitive (covalent) fashion in vitro, and may exert a long-lasting anticonvulsant effect.[3]

References[edit]

  1. ^ Edited by Ganellin, CR; Triggle, DJ (1999). Dictionary of Pharmacological Agents (1st ed.). London: Chapman & Hall. ISBN 9780412466304. 
  2. ^ Hall, Ian K.M. Morton, Judith M. (1999). Concise Dictionary of Pharmacological Agents Properties and Synonyms. Dordrecht: Springer Netherlands. p. 156. ISBN 978-94-011-4439-1. 
  3. ^ Williams, EF; Rice, KC; Mattson, M; Paul, SM; Skolnick, P (April 1981). "In Vivo Effects of Two Novel Alkylating Benzodiazepines, Irazepine and Kenazepine". Pharmacology Biochemistry and Behavior. 14 (4): 487–91. doi:10.1016/0091-3057(81)90307-5. PMID 7232472.