Iron-binding proteins

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Iron-binding proteins are carrier proteins and metalloproteins which play many important roles in various organic processes, including metabolism,[1] the immune response,[2] and delivery pathways for small molecules such as oxygen (when bound to iron in heme).[3] Iron is required by humans and bacteria for enzymes and metabolic pathways to function properly. Iron-binding proteins bind iron tightly, making it unavailable for microbial use, limiting the growth of foreign microbes. Four iron-binding proteins are Hemoglobin, Ferritin, lactoferrin and transferrin;

  • Hemoglobin is located in red blood cells.
  • Transferrin is found in blood and tissue fluids.
  • Lactoferrin is found in milk, blood, tears and saliva.
  • Ferritin is found in every cell type.

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  1. ^ Brock, JH. "Iron-binding proteins". Acta Paediatr Scand Suppl. 343. PMID 2485582. 
  2. ^ De Sousa, M; Breedvelt, F; Dynesius-Trentham, R; Trentham, D; Lum, J. "Iron, iron-binding proteins and immune system cells". Annals of the New York Academy of Sciences. 526. PMID 3291685. 
  3. ^ Kaplan, Jerry; Ward, Diane M. "The essential nature of iron usage and regulation". Current Biology. 23 (15). PMID 23928078.