Irwin McLean

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Irwin McLean
Professor Irwin McLean FMedSci FRS.jpg
BornWilliam Henry Irwin McLean
(1963-01-09) 9 January 1963 (age 55)[1]
Ballymoney, County Antrim[1]
Alma materQueen's University of Belfast (BSc, PhD, DSc)
Awards
Scientific career
Fields
InstitutionsUniversity of Dundee
ThesisElectrophoretic and immunological analysis of proteins in the muscular dystrophies (1988)
Websitelifesci.dundee.ac.uk/people/irwin-mclean

(William Henry) Irwin McLean (born 1963) FRS[2] FRSE FMedSci[3] is Professor of Human genetics, Head of the Division of Molecular Medicine and Scientific Director of the Centre for Dermatology and Genetic Medicine at the University of Dundee.[4][5][6][7][8][9][10]

Education[edit]

McLean was educated at Queen's University of Belfast where he was awarded a Bachelor of Science degree in Microbiology in 1985 followed by a PhD in 1988 for electrophoretic and immunological analysis of proteins involved in muscular dystrophy.[11]

Research[edit]

The McLean Lab investigates genetic disorders that affect the cells and tissues of the epithelium[12][13][14][15][16][17] and is funded by the Medical Research Council (MRC)[18] and is also currently supported by a strategic award from the Wellcome Trust (2012–2017).[19]

Awards and honours[edit]

McLean was elected a Fellow of the Royal Society in 2014. His nomination reads:

References[edit]

  1. ^ a b McLEAN, Prof. (William Henry) Irwin. ukwhoswho.com. Who's Who. 2015 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. closed access publication – behind paywall (subscription required)
  2. ^ a b c "Professor Irwin McLean FMedSci FRS". London: The Royal Society.
  3. ^ a b c Professor Irwin McLean FRS FRSE FMedSci, The Academy of Medical Sciences
  4. ^ Irwin McLean's publications indexed by the Scopus bibliographic database. (subscription required)
  5. ^ List of publications from Microsoft Academic
  6. ^ Palmer, C. N.; Irvine, A. D.; Terron-Kwiatkowski, A; Zhao, Y; Liao, H; Lee, S. P.; Goudie, D. R.; Sandilands, A; Campbell, L. E.; Smith, F. J.; O'Regan, G. M.; Watson, R. M.; Cecil, J. E.; Bale, S. J.; Compton, J. G.; Digiovanna, J. J.; Fleckman, P; Lewis-Jones, S; Arseculeratne, G; Sergeant, A; Munro, C. S.; El Houate, B; McElreavey, K; Halkjaer, L. B.; Bisgaard, H; Mukhopadhyay, S; McLean, W. H. (2006). "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis". Nature Genetics. 38 (4): 441–6. doi:10.1038/ng1767. PMID 16550169.
  7. ^ Smith, F. J.; Irvine, A. D.; Terron-Kwiatkowski, A; Sandilands, A; Campbell, L. E.; Zhao, Y; Liao, H; Evans, A. T.; Goudie, D. R.; Lewis-Jones, S; Arseculeratne, G; Munro, C. S.; Sergeant, A; O'Regan, G; Bale, S. J.; Compton, J. G.; Digiovanna, J. J.; Presland, R. B.; Fleckman, P; McLean, W. H. (2006). "Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris". Nature Genetics. 38 (3): 337–42. doi:10.1038/ng1743. PMID 16444271.
  8. ^ McLean, W. H.; Irvine, A. D. (2012). "Heritable filaggrin disorders: The paradigm of atopic dermatitis". The Journal of Investigative Dermatology. 132 (E1): E20–1. doi:10.1038/skinbio.2012.6. PMID 23154627.
  9. ^ Weidinger, S; Illig, T; Baurecht, H; Irvine, A. D.; Rodriguez, E; Diaz-Lacava, A; Klopp, N; Wagenpfeil, S; Zhao, Y; Liao, H; Lee, S. P.; Palmer, C. N.; Jenneck, C; Maintz, L; Hagemann, T; Behrendt, H; Ring, J; Nothen, M. M.; McLean, W. H.; Novak, N (2006). "Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations". The Journal of Allergy and Clinical Immunology. 118 (1): 214–9. doi:10.1016/j.jaci.2006.05.004. PMID 16815158.
  10. ^ "Molecular Dermatology: Methods and Protocols". doi:10.1007/978-1-62703-227-8. ISBN 9781627032261.
  11. ^ McLean, William Henry Irwin (1988). Electrophoretic and immunological analysis of proteins in the muscular dystrophies (PhD thesis). Queen's University of Belfast.
  12. ^ Research in the McLean Lab, University of Dundee
  13. ^ Nomura, T; Sandilands, A; Akiyama, M; Liao, H; Evans, A. T.; Sakai, K; Ota, M; Sugiura, H; Yamamoto, K; Sato, H; Palmer, C. N.; Smith, F. J.; McLean, W. H.; Shimizu, H (2007). "Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis". The Journal of Allergy and Clinical Immunology. 119 (2): 434–40. doi:10.1016/j.jaci.2006.12.646. PMID 17291859.
  14. ^ Basu, K; Palmer, C. N.; Lipworth, B. J.; Irwin Mclean, W. H.; Terron-Kwiatkowski, A; Zhao, Y; Liao, H; Smith, F. J.; Mitra, A; Mukhopadhyay, S (2008). "Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults". Allergy. 63 (9): 1211–7. doi:10.1111/j.1398-9995.2008.01660.x. PMID 18307574.
  15. ^ Palmer, C. N.; Ismail, T; Lee, S. P.; Terron-Kwiatkowski, A; Zhao, Y; Liao, H; Smith, F. J.; McLean, W. H.; Mukhopadhyay, S (2007). "Filaggrin null mutations are associated with increased asthma severity in children and young adults". The Journal of Allergy and Clinical Immunology. 120 (1): 64–8. doi:10.1016/j.jaci.2007.04.001. PMID 17531295.
  16. ^ Henderson, J; Northstone, K; Lee, S. P.; Liao, H; Zhao, Y; Pembrey, M; Mukhopadhyay, S; Smith, G. D.; Palmer, C. N.; McLean, W. H.; Irvine, A. D. (2008). "The burden of disease associated with filaggrin mutations: A population-based, longitudinal birth cohort study". The Journal of Allergy and Clinical Immunology. 121 (4): 872–7.e9. doi:10.1016/j.jaci.2008.01.026. PMID 18325573.
  17. ^ Bisgaard, H; Simpson, A; Palmer, C. N.; Bønnelykke, K; McLean, I; Mukhopadhyay, S; Pipper, C. B.; Halkjaer, L. B.; Lipworth, B; Hankinson, J; Woodcock, A; Custovic, A (2008). "Gene-environment interaction in the onset of eczema in infancy: Filaggrin loss-of-function mutations enhanced by neonatal cat exposure". PLOS Medicine. 5 (6): e131. doi:10.1371/journal.pmed.0050131. PMC 2504043. PMID 18578563.
  18. ^ UK Government research grants awarded to Irwin McLean, via Research Councils UK
  19. ^ Wellcome Trust strategic awards 2013