|Full name||Isaác Brizuela Muñoz|
|Date of birth||28 August 1990|
|Place of birth||San Jose, California, United States|
|Height||1.73 m (5 ft 8 in)|
|2013||→ Atlas (loan)||18||(2)|
|* Senior club appearances and goals counted for the domestic league only and correct as of 20 November 2016.
‡ National team caps and goals correct as of 10 June 2014
Brizuela was born in the United States to Mexican parents who worked in California at the time. His family returned to their hometown of Lagos de Moreno, Jalisco when he was two-years-old. He began playing football in his town until he was scouted to play for Toluca's youth squad in Guadalajara. Brizuela was promoted to the club's first-team squad in 2009 after good performances with the club's farm team, Atlético Mexiquense, from the second division. He also had a brief loan-spell with Club Atlas in 2013.
He is commonly referred to by his nickname Conejito (Spanish: little rabbit.)
Brizuela debuted with Toluca on 26 July 2009 in the 2009 Apertura against Guadalajara. He won the 2010 Bicentenario tournament with Toluca, his first professional championship. In January 2013 Brizuela was loaned to Atlas for six months in order to get more playing time. His successful campaign at Atlas, where he was crucial for the team finishing the 2013 Clausura in third place, entering the quarterfinals and avoiding relegation, prompted Toluca coach José Cardozo to include him in the club's squad once again.
On 17 December 2014 C.D. Guadalajara announced that they had signed Brizuela. Guadalajara owner Jorge Vergara revealed in an interview with ESPN's Fútbol Picante that Brizuela's transfer fee was more than 100 million pesos ($6.8 million). Brizuela made his debut on 10 January 2015 against Chiapas F.C. and the club lost 2-1.  On 30 August 2015 he scored his first league goal in a 4-1 win at home against Chiapas.
In May 2013, Brizuela revealed that he was born in San José, California to Mexican parents even though he had initially reported to the FMF (Mexican Football Federation) that he was born in Lagos de Moreno, Jalisco. Therefore, he was eligible to play for either the United States, even if he did not speak English, and Mexico. Mexico head coach José Manuel de la Torre listed Brizuela in Mexico's 35-man preliminary squad for the Gold Cup due to his good performances with Atlas. He was subsequently included in the final 23-player squad. Brizuela made his first competitive appearance for Mexico with the senior squad in a 2013 CONCACAF Gold Cup match against Panama that also, given his dual US-Mexican citizenship, cap-tied him to Mexico. He was included in Miguel Herrera 23-man world cup squad, but didn't appear in any matches.
- Club Toluca
- Isaác Brizuela – Liga MX stats at MedioTiempo.com (Spanish)
- "Comunicado de Prensa (Isaac Brizuela)". C.D. Guadalajara. 18 December 2014. Retrieved 18 December 2014.
- "CHIAPAS 2-1 CHIVAS PRESIÓN ROJIBLANCA". futboltotal.com.mx. 10 January 2015. Retrieved 18 January 2015.
- "¡CHIVAS CAMPEÓN DE LA COPA MX APERTURA 2015!". chivasdecorazon.com.mx. 4 November 2015. Retrieved 5 November 2015.
- "Hace historia en la Copa". chivasdecorazon.com.mx. 19 April 2017. Retrieved 19 April 2017.
- "¡Chivas Campeón de la SuperCopa MX!". chivasdecorazon.com.mx. 10 July 2016. Retrieved 10 July 2016.