Isaac Whood (1689–1752) was an English portrait-painter, working in the manner of Godfrey Kneller.
He was especially patronised by John Russell, 4th Duke of Bedford, for whom he painted numerous portraits of members of the Spencer and Russell families, destined for Woburn Abbey; some of these were copied by Whood from other painters. At Cambridge there are portraits by Whood at Trinity College, including one of Isaac Barrow, and at Trinity Hall. There is a portrait of Archbishop William Wake by Whood at Lambeth Palace, painted in 1736. 
Some of his portraits were engraved in mezzotint, notably one of Laurent Delvaux the sculptor, engraved by Alexander Van Haecken. Whood's drawings include some in chalk or blacklead. In 1743 he executed a series of designs to illustrate Samuel Butler's Hudibras. The portrait of Joseph Spence prefixed to his Anecdotes was engraved from a portrait by Whood.
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