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ISCA or Isca may refer to:

ISCA, a four letter abbreviation which may be one of:

Isca, any of several places in Roman Britain, derived from a Brythonic word for "flowing water":

Isca, a place in Calabria, Italy:

Other meanings:

  • Isca, a village in Meteș Commune, Alba County, Romania
  • Alternate transliteration of Iscah, daughter of Haran
  • Isca Academy